cGAMP
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货号：A982224
同义名：
Cyclic GMP-AMP;3',3'-cGAMP
cGAMP 是一种内源性第二信使，可以诱导细胞因子的形成并促进先天免疫反应。它通过激活干扰素基因刺激因子 (STING) 触发信号级联反应，进而产生 I 型干扰素和其他免疫介质，具有抗肿瘤活性。
cGAMP 化学结构
cGAMP 3D分子结构
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cGAMP 纯度/质量文件 产品仅供科研
货号：A982224
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cGAMP 质控信息
cGAMP 生物活性
描述
cGAMP (cyclic-GMP-AMP) functions as an endogenous second messenger that triggers interferon production in response to cytosolic DNA. It is a STING ligand which binds to STING, leading to the activation of IRF3 and induction of interferon-β[4] [5] IFNB1 [6]
cGAMP 动物研究
Dose
Mice: 0.5 mg/kg - 20 mg/kg[4]
Administration
p.o.
cGAMP 参考文献
[1] Wu J, Sun L, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30.
[2] Ablasser A, Schmid-Burgk JL, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4.
[3] Liu Y, Jesus AA, et al. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 2014 Aug 7;371(6):507-518.
[4] Wu J, Sun L, Chen X, Du F, Shi H, Chen C, Chen ZJ. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30. doi: 10.1126/science.1229963. Epub 2012 Dec 20. PMID: 23258412; PMCID: PMC3855410.
[5] Ablasser A, Schmid-Burgk JL, Hemmerling I, Horvath GL, Schmidt T, Latz E, Hornung V. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4. doi: 10.1038/nature12640. Epub 2013 Sep 29. PMID: 24077100; PMCID: PMC4142317.
[6] Liu Y, Jesus AA, Marrero B, Yang D, Ramsey SE, Sanchez GAM, Tenbrock K, Wittkowski H, Jones OY, Kuehn HS, Lee CR, DiMattia MA, Cowen EW, Gonzalez B, Palmer I, DiGiovanna JJ, Biancotto A, Kim H, Tsai WL, Trier AM, Huang Y, Stone DL, Hill S, Kim HJ, St Hilaire C, Gurprasad S, Plass N, Chapelle D, Horkayne-Szakaly I, Foell D, Barysenka A, Candotti F, Holland SM, Hughes JD, Mehmet H, Issekutz AC, Raffeld M, McElwee J, Fontana JR, Minniti CP, Moir S, Kastner DL, Gadina M, Steven AC, Wingfield PT, Brooks SR, Rosenzweig SD, Fleisher TA, Deng Z, Boehm M, Paller AS, Goldbach-Mansky R. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 2014 Aug 7;371(6):507-518. doi: 10.1056/NEJMoa1312625. Epub 2014 Jul 16. PMID: 25029335; PMCID: PMC4174543.
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cGAMP 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
1.48mL
0.30mL
0.15mL
7.41mL
1.48mL
0.74mL
14.83mL
2.97mL
1.48mL
cGAMP 技术信息
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