生物活性 | |||
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描述 | cGAMP (cyclic-GMP-AMP) functions as an endogenous second messenger that triggers interferon production in response to cytosolic DNA. It is a STING ligand which binds to STING, leading to the activation of IRF3 and induction of interferon-β[4]. cGAS-synthesized cGAMP is transferred from producing cells to neighbouring cells through gap junctions, where it promotes STING activation and thus antiviral immunity independently of type I IFN signaling, identifying cGAS-triggered cGAMP transfer as a novel host strategy that serves to rapidly convey antiviral immunity in a transcription-independent, horizontal manner[5]. On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1[6]. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.48mL 0.30mL 0.15mL |
7.41mL 1.48mL 0.74mL |
14.83mL 2.97mL 1.48mL |
参考文献 |
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