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α-乳香酸 /alpha-Boswellic acid {[allProObj[0].p_purity_real_show]}

货号:A425124 同义名: α-Boswellic acid

alpha-Boswellic acid是一种从乳香中提取的五环三萜类化合物,具有抗炎和抗肿瘤作用。

alpha-Boswellic acid 化学结构 CAS号:471-66-9
alpha-Boswellic acid 化学结构
CAS号:471-66-9
alpha-Boswellic acid 3D分子结构
CAS号:471-66-9
alpha-Boswellic acid 化学结构 CAS号:471-66-9
alpha-Boswellic acid 3D分子结构 CAS号:471-66-9
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alpha-Boswellic acid 纯度/质量文件 产品仅供科研

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alpha-Boswellic acid 生物活性

描述 alpha-Boswellic acid is a natural product isolated and purified from the herbs of Boswellia carterii Birdw. The binding of the cid) and BBA (beta-Boswellic acid) with the spike of the virus could inhibit its reproduction or provide sufficient time for the immune system to recognize the virus and hence, produce suitable antibodies[3]. In addition, boswellic acids have an antiproliferative effect on tumours. They inhibit proliferation of tumour cells of the leukaemia and glioblastoma subset. They have an anti-tumour effect since they inhibit topoisomerase I and II-alpha and stimulate programmed cell death (apoptosis)[4]. More than 50% of the cells underwent apoptosis after treatment with 20 mug/mL boswellic acid for 24 hours. Boswellic acid acetate induced Bid cleavage and decreased mitochondrial membrane potential without production of hydrogen peroxide[5].

alpha-Boswellic acid 参考文献

[1]Fathi E, Katouli FH, et al. The Effects of Alpha Boswellic Acid on Reelin Expression and Tau Phosphorylation in Human Astrocytes. Neuromolecular Med. 2017 Mar;19(1):136-146.

[2]Zhang Y, Jia J, et al. Alpha-boswellic acid protects against ethanol-induced gastric injury in rats: involvement of nuclear factor erythroid-2-related factor 2/heme oxygenase-1 pathway. J Pharm Pharmacol. 2016 Apr;68(4):514-22.

[3]Kadhim MM, Washeel Salman A, Mrebee Zarzoor A, Kadhum WR. Inhibition of SARS-CoV-2 reproduction using Boswellia carterii: A theoretical study. J Mol Liq. 2021 Sep 1;337:116440

[4]Al-Yasiry AR, Kiczorowska B. Frankincense--therapeutic properties. Postepy Hig Med Dosw (Online). 2016 Jan 4;70:380-91

[5]Xia L, Chen D, Han R, Fang Q, Waxman S, Jing Y. Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells. Mol Cancer Ther. 2005 Mar;4(3):381-8

alpha-Boswellic acid 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.19mL

0.44mL

0.22mL

10.95mL

2.19mL

1.09mL

21.90mL

4.38mL

2.19mL

alpha-Boswellic acid 技术信息

CAS号471-66-9
分子式C30H48O3
分子量 456.7
别名 α-Boswellic acid
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Inert atmosphere,Room temperature

溶解方案

DMSO: 25 mg/mL(54.74 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方
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