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/ Zeaxanthin

玉米黄素 /Zeaxanthin {[allProObj[0].p_purity_real_show]}

货号：A132185 同义名： Anchovyxanthin;Zeaxanthol

Zeaxanthin, a dihydroxy carotenoid isolated and purified from the fruits of Zea mays L., is one of the two diet-obtained carotenoids present in the macula region of the eye, and has been shown to contain antioxidant and anti-inflammation characteristics.

Zeaxanthin 化学结构 CAS号：144-68-3
Zeaxanthin 化学结构
CAS号：144-68-3
Zeaxanthin 3D分子结构
CAS号：144-68-3
Zeaxanthin 化学结构 CAS号：144-68-3
Zeaxanthin 3D分子结构 CAS号：144-68-3
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Zeaxanthin 纯度/质量文件 产品仅供科研

货号：A132185 标准纯度： {[allProObj[0].p_purity_real_show]}
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Zeaxanthin 生物活性

描述 Zeaxanthin, a dihydroxy carotenoid isolated and purified from the fruits of Zea mays L., is one of the two diet-obtained carotenoids present in the macula region of the eye[3]. Zeaxanthin shows antioxidant effects[4]. Zeaxanthin is known as one of the most important and common xanthophyll carotenoids, possessing multiple therapeutic effects such as strong antioxidant and pro-oxidant behaviour as well as anti-inflammatory effects. Zeaxanthin mitigates ocular problems and suppresses oxidative stress in the retinal tissues[5]. The macular pigment can be increased in primates by either increasing the intake of foods that are rich in lutein and zeaxanthin, such as dark-green leafy vegetables, or by supplementation with lutein or zeaxanthin[6]. ZEA (Zeaxanthin) treated adipocytes demonstrated a brown-like pattern, with upregulated expression of uncoupling protein 1 (UCP1) and other brown adipocyte markers. In addition, ZEA intervention induced a dramatic increase in mitochondrial DNA (mtDNA) content and in the mRNA levels of genes associated with mitochondrial biogenesis. Furthermore, ZEA attenuated mitochondrial oxidative damage caused by lipid peroxidation in adipocytes, significantly improved the mitochondrial membrane potential (MMP), and scavenged intracellular reactive oxygen species (ROS) and mitochondrial superoxide. ZEA promoted the expression of brown and beige adipogenesis markers and mitochondrial biogenesis, which involved AMPKα1 activation, thus contributing to the anti-obesity effects of ZEA[7].

Zeaxanthin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00914576 Healthy Not Applicable Completed - Austria ... 展开 >> Department of Clinical Pharmacology, Medical University of Vienna Vienna, Austria, 1090 收起 <<
NCT03433885 - Active, not recruiting December 31, 2023 China, Zhejiang ... 展开 >> The eye hospital of Wenzhou Medical University Wenzhou, Zhejiang, China, 325000 收起 <<
NCT00732173 Endometrial Cancer Not Applicable Completed - United States, Ohio ... 展开 >> Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44106-5065 收起 <<

Zeaxanthin 参考文献

[1]Johnson EJ. Role of lutein and zeaxanthin in visual and cognitive function throughout the lifespan. Nutr Rev. 2014 Sep;72(9):605-12.

[2]Bone RA, Landrum JT, et al. Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans. J Nutr. 2003 Apr;133(4):992-8. Erratum in: J Nutr. 2003 Jun;133(6):1953.

[3]Bone RA, Landrum JT, Friedes LM, Gomez CM, Kilburn MD, Menendez E, Vidal I, Wang W. Distribution of lutein and zeaxanthin stereoisomers in the human retina. Exp Eye Res. 1997 Feb;64(2):211-8

[4]Elbaz-Hayoun S, Rinsky B, Hagbi-Levi S, Grunin M; Tammy HayaYedid, Chowers I. Evaluation of antioxidant treatments for the modulation of macrophage function in the context of retinal degeneration. Mol Vis. 2019 Sep 5;25:479-488

[5]Manikandan R, Thiagarajan R, Goutham G, Arumugam M, Beulaja M, Rastrelli L, Skalicka-Woźniak K, Habtemariam S, Orhan IE, Nabavi SF, Nabavi SM. Zeaxanthin and ocular health, from bench to bedside. Fitoterapia. 2016 Mar;109:58-66

[6]Krinsky NI, Landrum JT, Bone RA. Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annu Rev Nutr. 2003;23:171-201

[7]Liu M , Zheng M , Cai D , Xie J , Jin Z , Liu H , Liu J . Zeaxanthin promotes mitochondrial biogenesis and adipocyte browning via AMPKα1 activation. Food Funct. 2019 Apr 17;10(4):2221-2233

Zeaxanthin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.76mL

0.35mL

0.18mL

8.79mL

1.76mL

0.88mL

17.58mL

3.52mL

1.76mL

Zeaxanthin 技术信息

CAS号144-68-3
分子式C40H56O2
分子量 568.871
别名 Anchovyxanthin;Zeaxanthol;beta-Carotene-3,3'-diol;Xanthophyll 3
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C
溶解度

THF: 10 mg/mL(17.58 mM)
动物实验配方

Tags: Zeaxanthin | Anchovyxanthin;Zeaxanthol;beta-Carotene-3,3'-diol;Xanthophyll 3 | Endogenous Metabolite | Zea | AmBeed-信号通路专用抑制剂 | Zeaxanthin 纯度/质量文件 | Zeaxanthin 生物活性 | Zeaxanthin 临床数据 | Zeaxanthin 参考文献 | Zeaxanthin 实验方案 | Zeaxanthin 技术信息

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