Zeaxanthin

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Chemical Structure| 144-68-3 同义名 : Anchovyxanthin;Zeaxanthol;beta-Carotene-3,3'-diol;Xanthophyll 3
CAS号 : 144-68-3
货号 : A132185
分子式 : C40H56O2
纯度 : 98%+
分子量 : 568.871
MDL号 : MFCD08435940
存储条件：

Pure form Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

THF: 10 mg/mL(17.58 mM)
动物实验配方：
生物活性
描述 Zeaxanthin, a dihydroxy carotenoid isolated and purified from the fruits of Zea mays L., is one of the two diet-obtained carotenoids present in the macula region of the eye[3]. Zeaxanthin shows antioxidant effects[4]. Zeaxanthin is known as one of the most important and common xanthophyll carotenoids, possessing multiple therapeutic effects such as strong antioxidant and pro-oxidant behaviour as well as anti-inflammatory effects. Zeaxanthin mitigates ocular problems and suppresses oxidative stress in the retinal tissues[5]. The macular pigment can be increased in primates by either increasing the intake of foods that are rich in lutein and zeaxanthin, such as dark-green leafy vegetables, or by supplementation with lutein or zeaxanthin[6]. ZEA (Zeaxanthin) treated adipocytes demonstrated a brown-like pattern, with upregulated expression of uncoupling protein 1 (UCP1) and other brown adipocyte markers. In addition, ZEA intervention induced a dramatic increase in mitochondrial DNA (mtDNA) content and in the mRNA levels of genes associated with mitochondrial biogenesis. Furthermore, ZEA attenuated mitochondrial oxidative damage caused by lipid peroxidation in adipocytes, significantly improved the mitochondrial membrane potential (MMP), and scavenged intracellular reactive oxygen species (ROS) and mitochondrial superoxide. ZEA promoted the expression of brown and beige adipogenesis markers and mitochondrial biogenesis, which involved AMPKα1 activation, thus contributing to the anti-obesity effects of ZEA[7].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00914576 Healthy Not Applicable Completed - Austria ... 展开 >> Department of Clinical Pharmacology, Medical University of Vienna Vienna, Austria, 1090 收起 <<
NCT03433885 - Active, not recruiting December 31, 2023 China, Zhejiang ... 展开 >> The eye hospital of Wenzhou Medical University Wenzhou, Zhejiang, China, 325000 收起 <<
NCT00732173 Endometrial Cancer Not Applicable Completed - United States, Ohio ... 展开 >> Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44106-5065 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.76mL

0.35mL

0.18mL

8.79mL

1.76mL

0.88mL

17.58mL

3.52mL

1.76mL
参考文献

[1]Johnson EJ. Role of lutein and zeaxanthin in visual and cognitive function throughout the lifespan. Nutr Rev. 2014 Sep;72(9):605-12.

[2]Bone RA, Landrum JT, et al. Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans. J Nutr. 2003 Apr;133(4):992-8. Erratum in: J Nutr. 2003 Jun;133(6):1953.

[3]Bone RA, Landrum JT, Friedes LM, Gomez CM, Kilburn MD, Menendez E, Vidal I, Wang W. Distribution of lutein and zeaxanthin stereoisomers in the human retina. Exp Eye Res. 1997 Feb;64(2):211-8

[4]Elbaz-Hayoun S, Rinsky B, Hagbi-Levi S, Grunin M; Tammy HayaYedid, Chowers I. Evaluation of antioxidant treatments for the modulation of macrophage function in the context of retinal degeneration. Mol Vis. 2019 Sep 5;25:479-488

[5]Manikandan R, Thiagarajan R, Goutham G, Arumugam M, Beulaja M, Rastrelli L, Skalicka-Woźniak K, Habtemariam S, Orhan IE, Nabavi SF, Nabavi SM. Zeaxanthin and ocular health, from bench to bedside. Fitoterapia. 2016 Mar;109:58-66

[6]Krinsky NI, Landrum JT, Bone RA. Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annu Rev Nutr. 2003;23:171-201

[7]Liu M , Zheng M , Cai D , Xie J , Jin Z , Liu H , Liu J . Zeaxanthin promotes mitochondrial biogenesis and adipocyte browning via AMPKα1 activation. Food Funct. 2019 Apr 17;10(4):2221-2233