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2′,3′-二脱氧胞苷 /Zalcitabine 99%

货号:A310205 同义名: 扎西他滨 / 2',3'-Dideoxycytidine;ddC

Zalcitabine是一种核苷类似物逆转录酶抑制剂(NRTI),具有抗逆转录病毒活性,广泛用于HIV感染的研究。

Zalcitabine 化学结构 CAS号:7481-89-2
Zalcitabine 化学结构
CAS号:7481-89-2
Zalcitabine 3D分子结构
CAS号:7481-89-2
Zalcitabine 化学结构 CAS号:7481-89-2
Zalcitabine 3D分子结构 CAS号:7481-89-2
规格 价格 库存 数量
10mM*1mL(DMSO) ¥450 现货 - +
10mg ¥300 现货 - +
50mg ¥360 现货 - +
100mg ¥528 现货 - +
1g ¥3907 现货 - +
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Zalcitabine 纯度/质量文件 产品仅供科研

货号:A310205 标准纯度: 99%
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Zalcitabine 生物活性

描述 Zalcitabine is a potent nucleoside analogue reverse transcriptase inhibitor used in the treatment of HIV infection. Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminating elongation of the proviral DNA chain[3]. Zalcitabine exhibits the inhibition effect on the cellular uptake of [3H]-PAH in CHO/hOAT1 cells with an IC50 value of 1.23 mM. Furthermore, the cellular uptake of zalcitabine increased threefold with the enhancement of hOATI activity in CHO/hOAT1 cells[4].

Zalcitabine 参考文献

[1]Jin MJ, Han HK. Interaction of zalcitabine with human organic anion transporter 1. Pharmazie. 2006 May;61(5):491-2.

[2]Yarchoan R, Klecker RW, et al. Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex. Lancet. 1986 Mar 15;1(8481):575-80.

[3]Adkins JC, Peters DH, Faulds D. Zalcitabine. An update of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of HIV infection. Drugs. 1997;53(6):1054-1080.

[4]Jin MJ, Han HK. Interaction of zalcitabine with human organic anion transporter 1. Pharmazie. 2006;61(5):491-492.

Zalcitabine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.73mL

0.95mL

0.47mL

23.67mL

4.73mL

2.37mL

47.34mL

9.47mL

4.73mL

Zalcitabine 技术信息

CAS号7481-89-2
分子式C9H13N3O3
分子量 211.218
别名 扎西他滨 ;2',3'-Dideoxycytidine;ddC;dideoxycytidine, Brand name: Hivid.;2′-3′-dideoxycytidine;2’,3’-Dideoxycytidine;Ro 24-2027/000;NSC 606170;Dideoxycytidine
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: 60 mg/mL(284.07 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 25 mg/mL(118.36 mM)

动物实验配方

PO 0.5% CMC-Na 30 mg/mL clear

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