货号:A310205 同义名: 扎西他滨 / 2',3'-Dideoxycytidine;ddC
Zalcitabine是一种核苷类似物逆转录酶抑制剂(NRTI),具有抗逆转录病毒活性,广泛用于HIV感染的研究。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10mM*1mL(DMSO) | ¥450 | 现货 | - + |
10mg | ¥300 | 现货 | - + |
50mg | ¥360 | 现货 | - + |
100mg | ¥528 | 现货 | - + |
1g | ¥3907 | 现货 | - + |
快速发货 顺丰冷链运输,1-2 天到达
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免费溶解
描述 | Zalcitabine is a potent nucleoside analogue reverse transcriptase inhibitor used in the treatment of HIV infection. Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminating elongation of the proviral DNA chain[3]. Zalcitabine exhibits the inhibition effect on the cellular uptake of [3H]-PAH in CHO/hOAT1 cells with an IC50 value of 1.23 mM. Furthermore, the cellular uptake of zalcitabine increased threefold with the enhancement of hOATI activity in CHO/hOAT1 cells[4]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM | 4.73mL 0.95mL 0.47mL | 23.67mL 4.73mL 2.37mL | 47.34mL 9.47mL 4.73mL |
CAS号 | 7481-89-2 |
分子式 | C9H13N3O3 |
分子量 | 211.218 |
别名 | 扎西他滨 ;2',3'-Dideoxycytidine;ddC;dideoxycytidine, Brand name: Hivid.;2′-3′-dideoxycytidine;2’,3’-Dideoxycytidine;Ro 24-2027/000;NSC 606170;Dideoxycytidine |
运输 | 蓝冰 |
存储条件 | 液体 -20°C:3-6个月-80°C:12个月 粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
溶解度 | DMSO: 60 mg/mL(284.07 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 25 mg/mL(118.36 mM) |
动物实验配方 | PO 0.5% CMC-Na 30 mg/mL clear |