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雷公藤次碱 /Wilforine {[allProObj[0].p_purity_real_show]}

货号:A620428 同义名: WR

Wilforine is a natural product isolated and purified from the vines of Tripterygium wilfordii, with insecticidal activity by inhibiting the Na+-K+-ATPase in the central nervous system, and anti-inflammatory effect, which might be mediated by down-regulation of the expression of inflammatory factors TNF-α,IL-6 and NO.

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Wilforine 化学结构 CAS号:11088-09-8
Wilforine 化学结构
CAS号:11088-09-8
Wilforine 3D分子结构
CAS号:11088-09-8
Wilforine 化学结构 CAS号:11088-09-8
Wilforine 3D分子结构 CAS号:11088-09-8
规格 价格 会员价 库存 数量
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Wilforine 纯度/质量文件 产品仅供科研

货号:A620428 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 P-gp 其他靶点 纯度
Elacridar BCRP 99%+
Zosuquidar 3HCl ++

P-gp, Ki: 60 nM

99%+
SC144 99%+
Tariquidar +++

P-gp, Kd: 5.1 nM

98%
Schizandrin B 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Wilforine 生物活性

描述 Wilforine is a natural product isolated and purified from the vines of Tripterygium wilfordii, with insecticidal activity by inhibiting the Na+-K+-ATPase in the central nervous system, and anti-inflammatory effect, which might be mediated by down-regulation of the expression of inflammatory factors TNF-α,IL-6 and NO.

Wilforine 参考文献

[1]Su MX, Song M, et al. Application of a sensitive and specific LC-MS/MS method for determination of wilforine from Tripterygium wilfordii Hook. F. in rat plasma for a bioavailability study. Biomed Chromatogr. 2015 Jul;29(7):1042-7.

[2]Zhu C, Miao G, et al. Establishment of Tripterygium wilfordii Hook. f. Hairy root culture and optimization of its culture conditions for the production of triptolide and wilforine. J Microbiol Biotechnol. 2014 Jun 28;24(6):823-34.

Wilforine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.15mL

0.23mL

0.12mL

5.76mL

1.15mL

0.58mL

11.52mL

2.30mL

1.15mL

Wilforine 技术信息

CAS号11088-09-8
分子式C43H49NO18
分子量 867.845
别名 WR
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: 50 mg/mL(57.61 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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