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维生素D相关/核受体
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/ VD/VDR / Vitamin D3

维生素D3 /Vitamin D3 {[allProObj[0].p_purity_real_show]}

货号：A146813 同义名： Cholecalciferol;Colecalciferol

Vitamin D3 是一种脂溶性维生素，具有调节钙和磷代谢的作用。Vitamin D3 主要用于骨骼健康、免疫功能和癌症预防的研究。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Vitamin D3 化学结构 CAS号：67-97-0
Vitamin D3 化学结构
CAS号：67-97-0
Vitamin D3 3D分子结构
CAS号：67-97-0
Vitamin D3 化学结构 CAS号：67-97-0
Vitamin D3 3D分子结构 CAS号：67-97-0
规格 价格 会员价 库存 数量
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Vitamin D3 纯度/质量文件 产品仅供科研

货号：A146813 标准纯度： {[allProObj[0].p_purity_real_show]}
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全球学术期刊中引用的产品

• Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]
• JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]
• BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]
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• PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]
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Vitamin D3 生物活性

描述 Vitamin D3 (Cholecalciferol) is a naturally occuring form of vitamin D. Cholecalciferol induces cell differentiation and prevents proliferation of cancer cells. Cholecalciferol (2-10 μM; 24-48 hours) exhibits anti-proliferative effects in a dose- and time- dependent manner. Maximal reduction of viability post treatment of 62% (IK), 52% (RL-95-2), and 55% (Hec-1A) occurrs by 72 h of treatment with 10 μM VD3. but 24-hour exposure lacks significant reduction in viable cells[3]. Active vitamin D3(calcitriol)and its derivatives(alfacalcidol, eldecalcitol), and vitamin K2(menatetrenone)are used as the therapeutic medicines for osteoporosis in Japan[4]. Elevated calcium levels were induced in mice by pre-treatment with cholecalciferol (vitamin D3; V.D3). Exposure to V.D3 alone had no effect on plasma markers of liver or kidney damage or on total antioxidant power or lipid peroxidation. The potentiating effect of V.D3 was positively correlated with elevation of hepatic calcium levels[5]. Supplementation with vitamin D3 and calcium reduces the risk of hip fractures and other nonvertebral fractures among elderly women[6].

Vitamin D3 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02076750 Inflammatory Bowel Diseases ... 展开 >> Skin Pigmentation 收起 << Phase 1 Phase 2 Completed - United States, Georgia ... 展开 >> Children's Healthcare of Atlanta, Egleston Children's Hospital Atlanta, Georgia, United States, 30322 Emory Children's Center Atlanta, Georgia, United States, 30322 收起 <<
NCT01608451 Locally Advanced Breast Cancer... 展开 >> and Large Operable Breast Cancer 收起 << Phase 3 Active, not recruiting December 2020 India ... 展开 >> Tata Memorial Hospital Mumbai, Maharashtra, India, 400012 收起 <<
NCT03754712 MDD Not Applicable Recruiting February 28, 2019 Bangladesh ... 展开 >> BSMMU Recruiting Dhaka, Bangladesh Contact: Tanzina Afrin, MBBS    01796372338    Tanzina.afrin800@gmail.com    Contact: Sultanul Arifin, MBBS    01723836535    Sam35th@gmail.com    Principal Investigator: Tanzina Afrin, MBBS 收起 <<

Vitamin D3 参考文献

[1]Ousley AM, Castillo HS, et al. A human vitamin D receptor mutant activated by cholecalciferol. J Steroid Biochem Mol Biol. 2011 Jul;125(3-5):202-10.

[2]Diesing D, Cordes T, et al. Vitamin D--metabolism in the human breast cancer cell line MCF-7. Anticancer Res. 2006 Jul-Aug;26(4A):2755-9.

[3]Bergadà L, Pallares J, Maria Vittoria A, Cardus A, Santacana M, Valls J, Cao G, Fernàndez E, Dolcet X, Dusso AS, Matias-Guiu X. Role of local bioactivation of vitamin D by CYP27A1 and CYP2R1 in the control of cell growth in normal endometrium and endometrial carcinoma. Lab Invest. 2014 Jun;94(6):608-22

[4]Tsugawa N. [Clinical Pharmacokinetics of Active Vitamin D3 and its derivatives, and Vitamin K2(Menatetrenone).]. Clin Calcium. 2016;26(11):1547-1558. Japanese

[5]Yoshioka H, Usuda H, Miura N, Fukuishi N, Nonogaki T, Onosaka S. Vitamin D3-induced hypercalcemia increases carbon tetrachloride-induced hepatotoxicity through elevated oxidative stress in mice. PLoS One. 2017 Apr 27;12(4):e0176524

[6]Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ. Vitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med. 1992 Dec 3;327(23):1637-42

Vitamin D3 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.60mL

0.52mL

0.26mL

13.00mL

2.60mL

1.30mL

26.00mL

5.20mL

2.60mL

Vitamin D3 技术信息

CAS号67-97-0
分子式C27H44O
分子量 384.638
别名 Cholecalciferol;Colecalciferol;Deparal;Vigorsan;Vigantol;Trivitan;Ricketon;Activated 7-dehydrocholesterol;Arachitol;Calciol;NSC 375571
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C
溶解度

DMSO: 105 mg/mL(272.98 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

30% PEG400+0.5% Tween80+5% propylene glycol+water 30 mg/mL suspension

Tags: Vitamin D3 | Cholecalciferol;Colecalciferol;Deparal;Vigorsan;Vigantol;Trivitan;Ricketon;Activated 7-dehydrocholesterol;Arachitol;Calciol;NSC 375571 | VD/VDR | AmBeed-信号通路专用抑制剂 | Vitamin D3 纯度/质量文件 | Vitamin D3 生物活性 | Vitamin D3 临床数据 | Vitamin D3 参考文献 | Vitamin D3 实验方案 | Vitamin D3 技术信息

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