Treosulfan | NSC 39069 | Alkylating Cytotoxic Agent | AmBeed-信号通路专用抑制剂

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Treosulfan {[allProObj[0].p_purity_real_show]}

货号：A667449 同义名： NSC 39069;Treosulphan

Treosulfan is an alkylating agent used for conventional, as well as high-dose chemotherapy regimens, whereby plasma concentrations over 500 μg/mL can be achieved.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Treosulfan 化学结构
CAS号：299-75-2

Treosulfan 3D分子结构
CAS号：299-75-2

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Treosulfan 纯度/质量文件产品仅供科研

货号：A667449 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

Treosulfan 生物活性

描述

Treosulfan, an alkylating agent, exhibits inhibitory activity against various cancer cell lines, including Panc-1, Miapaca-2, and Capan-2 cells, with IC50 values of 3.6 µg/mL, 1.8 µg/mL, and 2.1 µg/mL, respectively. At a concentration of 100 µg/mL, Treosulfan shows nearly complete cytotoxicity against these cell lines. Its combination with LY 188011 enhances anti-cancer activity, whereas combining Treosulfan with 5-FU results in an antagonistic effect on Panc-1 and Miapaca-2 cells at various concentrations^[1]. Furthermore, at 800 µg/mL, Treosulfan significantly affects erythrocyte morphology, increases annexin-V binding, intracellular calcium ([Ca2+].i), and reactive oxygen species (ROS) levels. The removal of extracellular Ca2+ neutralizes Treosulfan's effect on annexin-V binding^[2].

体内研究

At a dose of 1.5 g/kg/day, Treosulfan induces rapid myeloablation and depletes splenic B and T cells in mice. This dose also transiently stimulates interleukin-2 production in spleen cells without significantly affecting the synthesis of tumor necrosis factor-alpha (TNF-α) and/or interferon-gamma (IFN-γ)^[3].

体外研究

Furthermore, at 800 µg/mL, Treosulfan significantly affects erythrocyte morphology, increases annexin-V binding, intracellular calcium ([Ca2+].i), and reactive oxygen species (ROS) levels. The removal of extracellular Ca2+ neutralizes Treosulfan's effect on annexin-V binding^[2].

Treosulfan 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00427999	Prostate Cancer	Phase 2	Completed	-	Germany ... 展开 >> Novartis Investigative Site Bad Reichenhall, Germany, 83435 Novartis Investigative Site Bonn, Germany, 53105 Novartis Investigative Site Hamburg, Germany, 20246 Novartis Investigative Site Hamburg, Germany, 22607 Novartis Investigative Site Kassel, Germany, 34131 Novartis Investigative Site Markkleeberg, Germany, 04416 Novartis Investigative Site Passau, Germany, 94032 Novartis Investigative Site Planegg, Germany, 82152 Novartis Investigative Site Regensburg, Germany, 93053 Novartis Investigative Site Tübingen, Germany, 72076 收起 <<
NCT01423500	Lymphoblastic Leukemia, Acute,... 展开 >> Childhood; 收起 <<	Phase 3	Unknown	September 2016	Austria ... 展开 >> Universitätsklinik für Kinder- und Jugendheilkunde, Klin. Abt. f. Hämato-Onkologie Graz, Austria, 8036 Universitätsklinik für Kinder- und Jugendheilkunde Innsbruck, Austria, 6020 St. Anna Children's Hospital Vienna, Austria, A-1090 Czech Republic Department of Paediatric Haematology and Oncology HSCT-Unit Prague, Czech Republic, 15006 Denmark Pediatric Clinic II, Rigshospitalet Copenhagen, Denmark, 4074 France Pediatric Immuno-Hematology Unit Robert Debré Hospital Paris, France, 75935 Israel Rambam Medical Center Haifa, Israel, 31096 Schneider Children`s Medical Center of Israel Petach-Tikva, Israel, 49202 Italy Clinica Pediatrica dell`Universita di Milano Bicocca, Hospitale San Gerardo Monza, Italy, 20052 Netherlands Leiden University Hospital Leiden, Netherlands, 2300 Radboud University - Nijmegen Medical Centre Nijmegen, Netherlands, 6500 Department of Paediatric Haematology and Oncology, Wilhelmina Children's Hospital Utrecht, Netherlands, 3584 Poland University Hospital, Collegium Medicum UMK, Pediatric Hematology and Oncology Bydgoszcz, Poland, 85-094 Department of Transplantation, University Children's Hospital Cracow, Poland, 30-663 Children`s University Hospital - Hematology - Oncology Lublin, Poland, 20-093 Department of Pediadric Oncology, Hematology and Transplantology, University of Medical Sciences Poznan, Poland, 60-572 Wroclaw Medical University, Dept. of Children Hematology and Oncology Wroclaw, Poland, 50-345 Slovakia Department of Pediatric Bone Marrow Transplantation Unit, University Childrens´ Hospital Bratislava, Slovakia, 833 40 Sweden Department of Pediatric Oncology, Lund University Hospital Lund, Sweden, 221-85 Turkey Department of Pediatrics, Gülhane Military Medical Academy Ankara, Turkey, 06018 Dept. of Paediatrics - BMT Unit, School of Medicine, University of Ankara Ankara, Turkey, 06100 Department of Pediatric Hematology-Oncology and Pediatric Stem Cell Transplantation, Akdeniz University School of Medicine Antalya, Turkey, 07070 Department of Pediatric Hematology, Oncology and BMT, Istanbul School of Medicine Istanbul, Turkey, 343990 Pediatric BMT Centre, Ege University Izmir, Turkey, 35100 收起 <<
NCT01949129	Acute Lymphoblastic Leukaemia	Phase 2 Phase 3	Recruiting	April 2023	-

Treosulfan 参考文献

[1]Nitsch E, et al. Synergistic cytotoxic activity of treosulfan and LY 188011 in pancreatic cancer cell lines. Anticancer Res. 2014 Apr;34(4):1779-84.

[2]Peter T, et al. Programmed erythrocyte death following in vitro Treosulfan treatment. Cell Physiol Biochem. 2015;35(4):1372-80.

[3]Sjöö F, et al. Myeloablative and immunosuppressive properties of treosulfan in mice. Exp Hematol. 2006 Jan;34(1):115-21.

Treosulfan 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.59mL

0.72mL

0.36mL

17.97mL

3.59mL

1.80mL

35.93mL

7.19mL

3.59mL

Treosulfan 技术信息

CAS号	299-75-2
分子式	C₆H₁₄O₈S₂
分子量	278.301

别名	NSC 39069;Treosulphan;(2S,3S)-2,3-Dihydroxybutane-1,4diyl dimethanesulfonate.
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C

溶解度

DMSO: 105 mg/mL(377.29 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 50 mg/mL(179.66 mM)，配合低频超声助溶

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00427999	Prostate Cancer	Phase 2	Completed	-	Germany ... 展开 >> Novartis Investigative Site Bad Reichenhall, Germany, 83435 Novartis Investigative Site Bonn, Germany, 53105 Novartis Investigative Site Hamburg, Germany, 20246 Novartis Investigative Site Hamburg, Germany, 22607 Novartis Investigative Site Kassel, Germany, 34131 Novartis Investigative Site Markkleeberg, Germany, 04416 Novartis Investigative Site Passau, Germany, 94032 Novartis Investigative Site Planegg, Germany, 82152 Novartis Investigative Site Regensburg, Germany, 93053 Novartis Investigative Site Tübingen, Germany, 72076 收起 <<
NCT01423500	Lymphoblastic Leukemia, Acute,... 展开 >> Childhood; 收起 <<	Phase 3	Unknown	September 2016	Austria ... 展开 >> Universitätsklinik für Kinder- und Jugendheilkunde, Klin. Abt. f. Hämato-Onkologie Graz, Austria, 8036 Universitätsklinik für Kinder- und Jugendheilkunde Innsbruck, Austria, 6020 St. Anna Children's Hospital Vienna, Austria, A-1090 Czech Republic Department of Paediatric Haematology and Oncology HSCT-Unit Prague, Czech Republic, 15006 Denmark Pediatric Clinic II, Rigshospitalet Copenhagen, Denmark, 4074 France Pediatric Immuno-Hematology Unit Robert Debré Hospital Paris, France, 75935 Israel Rambam Medical Center Haifa, Israel, 31096 Schneider Children`s Medical Center of Israel Petach-Tikva, Israel, 49202 Italy Clinica Pediatrica dell`Universita di Milano Bicocca, Hospitale San Gerardo Monza, Italy, 20052 Netherlands Leiden University Hospital Leiden, Netherlands, 2300 Radboud University - Nijmegen Medical Centre Nijmegen, Netherlands, 6500 Department of Paediatric Haematology and Oncology, Wilhelmina Children's Hospital Utrecht, Netherlands, 3584 Poland University Hospital, Collegium Medicum UMK, Pediatric Hematology and Oncology Bydgoszcz, Poland, 85-094 Department of Transplantation, University Children's Hospital Cracow, Poland, 30-663 Children`s University Hospital - Hematology - Oncology Lublin, Poland, 20-093 Department of Pediadric Oncology, Hematology and Transplantology, University of Medical Sciences Poznan, Poland, 60-572 Wroclaw Medical University, Dept. of Children Hematology and Oncology Wroclaw, Poland, 50-345 Slovakia Department of Pediatric Bone Marrow Transplantation Unit, University Childrens´ Hospital Bratislava, Slovakia, 833 40 Sweden Department of Pediatric Oncology, Lund University Hospital Lund, Sweden, 221-85 Turkey Department of Pediatrics, Gülhane Military Medical Academy Ankara, Turkey, 06018 Dept. of Paediatrics - BMT Unit, School of Medicine, University of Ankara Ankara, Turkey, 06100 Department of Pediatric Hematology-Oncology and Pediatric Stem Cell Transplantation, Akdeniz University School of Medicine Antalya, Turkey, 07070 Department of Pediatric Hematology, Oncology and BMT, Istanbul School of Medicine Istanbul, Turkey, 343990 Pediatric BMT Centre, Ege University Izmir, Turkey, 35100 收起 <<
NCT01949129	Acute Lymphoblastic Leukaemia	Phase 2 Phase 3	Recruiting	April 2023	-
NCT01423747	Lymphoblastic Leukemia, Acute,... 展开 >> Childhood; 收起 <<	Phase 3	Unknown	September 2016	Austria ... 展开 >> Universitätsklinik für Kinder- und Jugendheilkunde, Klin. Abt. f. Hämato-Onkologie Graz, Austria, 8036 Universitätsklinik für Kinder- und Jugendheilkunde Innsbruck, Austria, 6020 St. Anna Kinderspital Vienna, Austria, 1090 Germany Charité Campus Virchow- Klinikum, Klinikum der Pädiatrie, Onkologie/Hämatologie/KMT Berlin, Germany, 13353 Klinik und Poliklinik für Kinderheilkunde, Hämatologie, Onkologie Dresden, Germany, 01307 Universitätsklinikum Düsseldorf, Klinik f. Kinderonkologie, Hämatologie u. Immunologie Düsseldorf, Germany, 40001 Klinik für Kinder und Jugendliche der Universität Erlangen-Nürnberg Erlangen, Germany, 91054 Universitätsklinikum Essen, Zentrum für Kinderheilkunde, Abt. für Hämatologie/Onkologie Essen, Germany, 45122 Klinik für Kinderheilkunde III, Hämatologie und Onkologie, Johann Wolfgang Goethe Universität Frankfurt am Main, Germany, 60590 Universitätsklinikum Freiburg, Zentrum für Kinderheilkunde und Jugendmedizin, Klinik IV: Päd. Hämatologie und Onkologie Freiburg, Germany, 79106 Zentrum für Kinderheilkunde, Abt. Hämatologie und Onkologie Giessen, Germany, 35385 Klinkum der Med. Fakultät der Martin-Luther-Universität Halle-Wittenberg, Uni. Klinik un Poliklinik für Kinder- und Jugendmedizin Halle, Germany, 06097 Universitätsklinikum Hamburg-Eppendorf, Kinderklinik, Abt. für Hämatologie und Onkologie Hamburg, Germany, 20246 Med. Hochschule Hannover, Päd. Hämatologie und Onkologie Hannover, Germany, 30625 Universitätskinderklinik, Päd. Hämatologie, Onkologie und Immunologie Heidelberg, Germany, 69120 Klinik für Knochenmarktransplantation Idar-Oberstein, Germany, 55743 Klinik für Kinder- und Jugendmedizin Jena, Germany, 07724 Universitätsklinikum Kiel, Klinik für Allgemeine Pädiatrie Kiel, Germany, 24105 Klinikum der Universität München, Dr. von Haunersches Kinderspital, Abt. für Hämatologie / Onkologie München, Germany, 80337 Städt. Krankenhaus München-Schwabing, Universitätskinderklinik der TU München, Germany, 80804 Universitätsklinikum Münster, Klinik und Poliklinik für Kinderheilkunde, päd. Hämatologie / Onkologie Münster, Germany, 48149 Univ.-Klinik für Kinderheilkunde und Jugendmedizin Tübingen, Germany, 72076 Universitätskinderklinik Ulm, Germany, 89075 Universitätsklinik, päd. Onkologie/Stammzelltransplantation Würzburg, Germany, 97080 收起 <<
NCT00925821	Multiple Myeloma	Phase 2	Completed	-	Germany ... 展开 >> Charité University Hospital - Virchow Klinikum Berlin, Germany Dresden University Hospital Dresden, Germany, 01307 Erlangen University Hospital Erlangen, Germany, 91054 Freiburg University Hospital Freiburg, Germany, 79106 Jena University Hospital Jena, Germany Kiel University Hospital Kiel, Germany, 24105 Munich Grosshadern University Hospital Munich, Germany, 81377 University Hospital of Munich Technical University Munich, Germany, 81675 Klinikum Nuremberg Nuremberg, Germany, 90419 Regensburg University Hospital Regensburg, Germany, 93053 Rostock University Hospital Rostock, Germany, 18057 Ulm University Hospital Ulm, Germany, 89081 收起 <<
NCT00427999	-		Completed	-	-
NCT02670564	Acute Lymphoblastic Leukemia	Phase 4	Recruiting	April 2023	Switzerland ... 展开 >> Hôpital Cantonal de Genève, Département de Pédiatrie Recruiting Geneva, Cansearch Laboratory, Switzerland, 1211 Contact: Marc Ansari, MD, PD +41 22 382 47 31 Marc.Ansari@hcuge.ch Universitäts-Kinderspital beider Basel (UKBB), Onkologie/Hämatologie Recruiting Basel, Switzerland, 4056 Contact: Nicolas Von der Weid + 41 61 704 12 12 nicolas.vonderweid@ukbb.ch HUG Hôpitaux Universitaire de Genève, Unité d'onco-hématologie pédiatrique Recruiting Geneva, Switzerland, 1211 Contact: Marc Ansari +41 22 372 47 31 Marc.Ansari@hcuge.ch Universitäts-Kinderspital Recruiting Zurich, Switzerland, 8032 Contact: Güngör Tayfun +41 44 266 74 92 tayfun.guengoer@kispi.uzh.ch 收起 <<
NCT03434704	Transplant-Related Hematologic... 展开 >> Malignancy Leukemia, Acute Myelodysplastic Syndromes Graft Vs Host Disease Fungal Infection 收起 <<	Phase 2	Recruiting	September 15, 2022	Italy ... 展开 >> Ospedale San Raffaele Recruiting Milano, Lombardia, Italy, 20132 Contact: Fabio Ciceri, MD 0039022643 ext 4289 ciceri.clinicaltrials@hsr.it Sub-Investigator: Raffaella Greco, MD Sub-Investigator: Jacopo Peccatori, MD Sub-Investigator: Maria Teresa Lupo Stanghellini, MD Sub-Investigator: Andrea Assanelli, MD Sub-Investigator: Consuelo Corti, MD 收起 <<
NCT00779714	Melanoma	Phase 3	Unknown	April 2013	Germany ... 展开 >> Dept of Dermatology, University of Aachen Recruiting Aachen, Germany, 52074 Principal Investigator: Hans F Merk, Prof. (MD) Dept of Dermatology, University of Berlin Charite Recruiting Berlin, Germany, 10117 Principal Investigator: Uwe Trefzer, PD (MD) Dept of Dermatology, University of Bochum Recruiting Bochum, Germany, 44791 Principal Investigator: Norbert Brockmeyer, Prof. (MD) Medizinisches Zentrum Bonn Friedensplatz Recruiting Bonn, Germany, 53111 Principal Investigator: Uwe Reinhold, Prof. (MD) Dept of Dermatology, University of Essen Recruiting Essen, Germany, 45147 Principal Investigator: Dirk Schadendorf, Prof. (MD) Dept of Dermatology, University of Frankfurt Recruiting Frankfurt / Main, Germany, 60590 Principal Investigator: Roland Kaufmann, Prof. (MD) Dermatology, Klinikum Frankfurt/Oder Recruiting Frankfurt/Oder, Germany, 15236 Principal Investigator: Anett Milling, Dr. (MD) Dept of Dermatology, University of Hannover Recruiting Hannover, Germany, 30449 Principal Investigator: Ralf Gutzmer, PD (MD) Dept of Dermatology, Saarland University Recruiting Homburg/Saar, Germany, 66421 Principal Investigator: Knuth Rass, Dr. (MD) Dept of Dermatology, University of Jena Recruiting Jena, Germany, 07740 Principal Investigator: Martin Kaatz, Dr. (MD) Dept of Dermatology, University of Schleswig-Holstein Campus Kiel Recruiting Kiel, Germany, 24105 Principal Investigator: Axel Hauschild, Prof. (MD) Dermatology, Klinikum Ludwishafen Recruiting Ludwigshafen, Germany, 67063 Principal Investigator: Edgar Dippel, Prof. (MD) Dept of Dermatology, University of Schleswig-Holstein Campus Luebeck Recruiting Luebeck, Germany, 23538 Principal Investigator: Patrick Terheyden, Dr. (MD) Dept of Dermatology, Univeristy of Magdeburg Recruiting Magdeburg, Germany, 39120 Principal Investigator: Martin Leverkus, Prof. (MD) Dept of Dermatology, University of Mainz Recruiting Mainz, Germany, 55131 Principal Investigator: Carmen Loquai, Dr. (MD) Dept of Dermatology, University of Mannheim Recruiting Mannheim, Germany, 68167 Principal Investigator: Jessica Hassel, Dr. (MD) Dept of Dermatology, University of Marburg Recruiting Marburg, Germany, 35033 Principal Investigator: Michael Hertl, Prof. (MD) Dept of Dermatology, University of Muenchen Recruiting Muenchen, Germany, 80337 Principal Investigator: Carola Berking, Prof. (MD) Dept of Dermatology, University of Muenster Recruiting Muenster, Germany, 48149 Principal Investigator: Cord Sunderkoetter, Prof. (MD) Dept of Medical Oncology, Fachklinik Hornheide Recruiting Muenster, Germany, 48157 Principal Investigator: Michael Fluck, Dr. (MD) Dermatology, Klinikum Dorothea Christiane Erxleben Recruiting Quedlinburg, Germany, 06484 Principal Investigator: Jens Ulrich, PD (MD) Dept of Dermatology, University of Tuebingen Recruiting Tuebingen, Germany, 72086 Principal Investigator: Claus Garbe, Prof. (MD) Dept of Dermatology, University of Wuerzburg Recruiting Wuerzburg, Germany, 97080 Principal Investigator: Selma Ugurel, Prof. (MD) 收起 <<
NCT00987636	Ewing's Sarcoma	Phase 3	Recruiting	March 2019	Germany ... 展开 >> University Children´s Hospital, Pediatric Hematology and Oncology Recruiting Muenster, Germany, 48149 Principal Investigator: Claudia Rössig, Prof MD Sub-Investigator: Uta Dirksen, Prof MD Sub-Investigator: Birgit Fröhlich, MD 收起 <<
NCT01582048	Patients Receiving Mismatched ... 展开 >>Allogeneic HCT 收起 <<	Phase 2	Terminated(slow enrollment)	-	Germany ... 展开 >> Hematology/Oncology Medical Center University Hospital of Mainz Mainz, Germany, D-55101 Bone Marrow Transplantation Unit Medical Center University Hospital of Nuernberg Nuernberg, Germany, D-90419 Department of Hematology/Oncology Medical Center University Hospital of Tuebingen Tuebingen, Germany, D-72076 BMT-Unit Deutsche Klinik für Diagnostik Wiesbaden, Germany, D-65191 收起 <<
NCT00168870	Ocular Melanoma	Phase 2	Unknown	-	Germany ... 展开 >> Hematology & Oncology Charité CBF Berlin Recruiting Berlin, Germany, 12203 Contact: Ulrich Keilholz, MD +49-30-8445-3596 ulrich.keilholz@charite.de Contact: Alexander Schmittel, MD +49-30-8445-3090 alexander.schmittel@charite.de Principal Investigator: Ulrich Keilholz, MD 收起 <<
NCT01894477	Acute Myeloid Leukemia in Remi... 展开 >>ssion Chronic Myelomonocytic Leukemia Minimal Residual Disease Myelodysplastic Syndrome Myelodysplastic/Myeloproliferative Neoplasm Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable 收起 <<	Phase 2	Active, not recruiting	January 2022	United States, Washington ... 展开 >> Fred Hutch/University of Washington Cancer Consortium Seattle, Washington, United States, 98109 收起 <<
NCT01894477	-		Active, not recruiting	-	-
NCT01010243	Multiple Myeloma	Phase 1 Phase 2	Unknown	October 2016	Germany ... 展开 >> Schön Klinik Starnberger See Recruiting Berg, Germany, 82335 Contact: Christian Straka, PD MD Principal Investigator: Christian Straka, PD MD Gemeinschaftspraxis Dres. med. J. Wilke u. H. Wagner Recruiting Fürth, Germany, 90766 Contact: Jochen Wilke, MD Principal Investigator: Jochen Wilke, MD Universitätsklinikum Schleswig-Holstein, II Medizin, Sekt. f. Stammzell- u. Immuntherapie Recruiting Kiel, Germany, 24105 Contact: Martin Gramatzki, Prof. MD Principal Investigator: Martin Gramatzki, Prof. MD Klinikum d. Universität München, Med. Klinik u. Poliklinik IV, Abt. H/O Recruiting München, Germany, 80336 Contact: Christian Adam, MD Principal Investigator: Christian Adam, MD Gemeinschaftspraxis Hämato/Onkologie Recruiting München, Germany, 81241 Contact: Burkhard Schmidt, MD Principal Investigator: Burkhard Schmidt, MD University of Regensburg Recruiting Regensburg, Germany, 93053 Contact: Albrecht Reichle, Professor albrecht.reichle@klinik.uni-regensburg.de Sub-Investigator: Matthias Grube, MD Sub-Investigator: Joachim Hahn, MD Sub-Investigator: Stephanie Mayer, MD Sub-Investigator: Martin Vogelhuber, MD Sub-Investigator: Christina Hart, MD Sub-Investigator: Karin Landfried, MD Sub-Investigator: Marco Petronio, MD Sub-Investigator: Dagmar Roll, MD Sub-Investigator: Tanja Zilch, MD 收起 <<
NCT00253513	Leukemia Myel... 展开 >>odysplastic Syndromes 收起 <<	Phase 1 Phase 2	Completed	-	United States, Oregon ... 展开 >> OHSU Knight Cancer Institute Portland, Oregon, United States, 97239-3098 United States, Washington Seattle Cancer Care Alliance Seattle, Washington, United States, 98109-1023 Fred Hutchinson Cancer Research Center Seattle, Washington, United States, 98109 收起 <<
NCT00796068	Acute Biphenotypic Leukemia ... 展开 >> Adult Acute Lymphoblastic Leukemia in Remission Adult Acute Myeloid Leukemia in Remission Adult Myelodysplastic Syndrome Blasts Under 5 Percent of Bone Marrow Nucleated Cells Childhood Acute Lymphoblastic Leukemia in Remission Childhood Acute Myeloid Leukemia in Remission Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive Childhood Myelodysplastic Syndrome Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive Myelodysplastic Syndrome With Excess Blasts-2 收起 <<	Phase 2	Recruiting	-	United States, Colorado ... 展开 >> University of Colorado Hospital Completed Aurora, Colorado, United States, 80045 United States, Oregon Oregon Health and Science University Completed Portland, Oregon, United States, 97239 United States, Washington Fred Hutch/University of Washington Cancer Consortium Recruiting Seattle, Washington, United States, 98109 Contact: Filippo Milano 206-667-5925 fmilano@fredhutch.org Principal Investigator: Filippo Milano 收起 <<
NCT00682305	Acute Lymphoblastic Leukemia	Phase 2	Completed	-	Germany ... 展开 >> University Medical Center Hamburg-Eppendorf Hamburg, Germany, 20246 收起 <<
NCT00860574	Accelerated Phase Chronic Myel... 展开 >>ogenous Leukemia Adult Acute Lymphoblastic Leukemia in Remission Adult Acute Myeloid Leukemia in Remission Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities Adult Acute Myeloid Leukemia With Del(5q) Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) Adult Acute Myeloid Leukemia With t(15;17)(q22;q12) Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) Blastic Phase Chronic Myelogenous Leukemia Childhood Acute Lymphoblastic Leukemia in Remission Childhood Acute Myeloid Leukemia in Remission Childhood Chronic Myelogenous Leukemia Childhood Myelodysplastic Syndromes Chronic Myelomonocytic Leukemia de Novo Myelodysplastic Syndromes Previously Treated Myelodysplastic Syndromes Recurrent Adult Acute Lymphoblastic Leukemia Recurrent Adult Acute Myeloid Leukemia Recurrent Childhood Acute Lymphoblastic Leukemia Recurrent Childhood Acute Myeloid Leukemia Secondary Myelodysplastic Syndromes Untreated Adult Acute Lymphoblastic Leukemia Untreated Childhood Acute Lymphoblastic Leukemia 收起 <<	Phase 2	Completed	-	United States, Colorado ... 展开 >> University of Colorado Denver, Colorado, United States, 80217-3364 United States, Oregon Oregon Health and Science University Portland, Oregon, United States, 97239 United States, Washington Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium Seattle, Washington, United States, 98109 收起 <<
NCT01810926	Graft Versus Host Disease	Phase 2	Unknown	October 2016	Italy ... 展开 >> University of Cagliari Active, not recruiting Cagliari, Italy, 09126 San Raffaele Scientific Institute Active, not recruiting Milano, Italy, 20132 University of Milano-Bicocca San Gerardo Hospital Active, not recruiting Monza, Italy, 20052 Bambino Gesù Hospital and Research Institute Recruiting Rome, Italy, 00165 Contact: Maria Ester Bernardo, MD mebernardo@gmail.com Principal Investigator: Franco Locatelli 收起 <<
NCT00170690	Ovarian Cancer	Phase 3	Completed	-	Germany ... 展开 >> Charité Campus Virchow-Klinikum Berlin, Germany, 13533 收起 <<
NCT00129155	Hematological Malignancies ... 展开 >> Allogeneic Transplantation 收起 <<	Phase 2	Unknown	-	France ... 展开 >> Hôpital Edouard Herriot Recruiting Lyon, France, 69437 Contact: Mauricette MICHALLET, MD 33 472 117 329 mauricette.michallet@chu-lyon.fr Principal Investigator: Mauricette Michallet, MD 收起 <<
NCT02852083	Squamous Cell Lung Cancer ... 展开 >> Non-Squamous Cell Lung Cancer Non-Small Cell Lung Cancer 收起 <<	Phase 2	Recruiting	July 2020	Germany ... 展开 >> Onkologische Gemeinschaftspraxis Dres. Wilke/ Wagner/Petzoldt Recruiting Fürth, Bavaria, Germany Contact: Traudl Gietl-Drescher 09119792220 info@onkologie-fuerth.de Klinikum Kempten Oberallgäu Recruiting Immenstadt, Bavaria, Germany Contact: Simone Eberl 08323-9108968 pneumologie.studien@kv-keoa.de MVZ am Klinikum GmbH Recruiting Passau, Bavaria, Germany Contact: Margit Schicht 085153002299 studiensekretariat@klinikum-passau.de Universitätsklinikum Regensburg Recruiting Regensburg, Bavaria, Germany Contact: Albrecht Reichle, MD albrecht.reichle@klinik.uni-regensburg.de Kliniken Nordoberpfalz AG, Klinikum Recruiting Weiden, Bavaria, Germany Contact: Gabriele Schulz Contact: Karola Dorner MVZ Weiden GmbH Recruiting Weiden, Bavaria, Germany Contact: Gabriele Schulze 09613033123 gabriele.schulze@kliniken-nordoberpfalz.ag Contact: Karola Dorner 09613033258 karola.dorner@kliniken-nordoberpfalz.ag St. Antonius-Hospital Recruiting Eschweiler, Nordrhein-Westfalen, Germany Contact: Susanne Recker 02403761737 studiensekretariat.onkologie@sah-eschweiler.de Klinik für Innere Medizin Recruiting Homburg/Saar, Saarland, Germany Contact: Thomas Wehler Thomas.Wehler@uks.eu Krankenhaus Martha-Maria Recruiting Halle (Saale), Sachsen-Anhalt, Germany Contact: Sabine Leysring 03455591434 studiensekretariat.schuette@nicsys.de 收起 <<
NCT00253513	-		Completed	-	-
NCT00822393	Acute Myeloid Leukemia ... 展开 >> Myelodysplastic Syndrome 收起 <<	Phase 3	Completed	-	Finland ... 展开 >> Helsinki University Central Hospital, Dept. of Medicine Helsinki, Finland, 00290 France Centre Hospitalier Lyon Sud Lyon, France, 69495 Hopital Saint-Louis Paris, France, 75475 Germany Universitätsklinikum Carl Gustav Carus Dresden, Med. Klinik I Dresden, Germany, 01307 Klinik für Knochenmarktransplantation Essen, Germany, 45122 Malteser Krankenhaus St. Franziskus-Hospital Flensburg, Germany, 24939 Universitätsklinikum Freiburg Freiburg, Germany, 79106 Universitätsmedizin Goettingen, Haematolgie und Onkologie Göttingen, Germany, 37075 Asklepios Kliniken Hamburg GmbH Hamburg, Germany, 20099 Universitätsklinikum Heidelberg Heidelberg, Germany, 69120 Friedrich-Schiller-Universität Jena Jena, Germany, 07747 Universitätsklinikum Koeln, Stammzelltransplantation Koeln, Germany, 50937 Universitätsklinikum Leipzig, Haematologie, internistische Onkologie Leipzig, Germany, 04109 Johannes-Gutenberg-Universität Mainz, III. Medizinische Klinik Mainz, Germany, 55131 Klinikum Rechts der Isar der TU München, III. Med. Klinik Muenchen, Germany, 81675 Universitätsklinikum Münster Münster, Germany, 48129 Klinikum Nürnberg, 5. Medizinische Klinik Nürnberg, Germany, 90419 Klinikum Oldenburg gGmbH Oldenburg, Germany, 26133 Klinikum der Universität Regensburg Regensburg, Germany, 93053 Universität Rostock Rostock, Germany, 18057 Universität Tübingen Tübingen, Germany, 72076 Stiftung Deutsche Klinik für Diagnostik Wiesbaden, Germany, 65191 Klinikum der Universität Würzburg Würzburg, Germany, 97070 Hungary St. Istvan and St. Laszlo Hospital of Budapest Budapest, Hungary, 1097 Italy Azienda Ospedaliera Papa Giovanni XXIII Bergamo, Italy, 24127 Hematology University of Brescia Brescia, Italy, 1-25123 Scientific Institute H. San Raffaele Milan, Italy, 20132 Ospedale Civile Pescara Pescara, Italy, 65123 Policlinico Umberto I Univ. La Sapienza Rome, Italy, 00161 Clinica Ematologica ed Unita di Terapie Cellulari 'Carlo Melzi' Udine, Italy, 33100 Policlinico GB Rossi (Borgo Roma), Div. di Ematologia Verona, Italy, 37134 Poland Medical University of Gdansk Gdansk, Poland, 80-952 Silesian Medical University Katowice, Poland, 40-032 收起 <<
NCT01079013	Non Hodgkin Lymphoma ... 展开 >> Hodgkin Lymphoma 收起 <<	Phase 2	Unknown	April 2018	Israel ... 展开 >> Chaim Sheba Medical Center Tel-Hashomer, Israel, 52621 收起 <<
NCT02349906	Primary Immunodeficiencies ... 展开 >> Inborn Errors of Metabolism Haemoglobinopathies Bone Marrow Failure Syndromes 收起 <<	Phase 2	Recruiting	December 2019	Austria ... 展开 >> St. Anna Children's Hospital Withdrawn Vienna, Austria, 1090 Czechia University Hospital Motol, Dep. of Paediatric Haematology and Oncology Recruiting Prague, Czechia Contact: Petr Sedlacek, MD, Prof. +42060672 ext 6550 Germany Department of Pediatric Oncology & Hematology, Charite Berlin Not yet recruiting Berlin, Germany, 13353 Contact: Johannes Schulte, MD, Prof. Duesseldorf University Hospital Withdrawn Duesseldorf, Germany, 40225 University Children's Hospital Essen Pediatric stem cell transplantation Not yet recruiting Essen, Germany, 45122 Contact: Rita Beier, MD University Hospital Frankfurt Recruiting Frankfurt am Main, Germany, 60590 Contact: Peter Bader, MD, Prof. University Medical Center Hamburg-Eppendorf Withdrawn Hamburg, Germany, 20246 Hannover Medical University, Dep. of Paediatrics, Paediatric Haematology and Oncology Recruiting Hannover, Germany Contact: Karl-Walter Sykora, MD, Prof. +49(0)511532 ext 5830 Heidelberg University Hospital Recruiting Heidelberg, Germany, 69120 Contact: Johann Greil, MD, Prof. University of Jena, Department of Pediatrics Not yet recruiting Jena, Germany, 07747 Contact: Bernd Gruhn, MD, Prof. University Hospital Regensburg Withdrawn Regensburg, Germany, 93053 Ulm, University Hospital, Clinic for Children and Adolescents Recruiting Ulm, Germany, 89075 Contact: Ansgar Schulz, MD, Prof. +49(0)731500 ext 57154 University Hospital of Wuerzburg Withdrawn Wuerzburg, Germany, 97080 Italy SC Oncoematologia Pediatrica Ospedale Pediatrico Microcitemico "Antonio Cao" A.O. Brotzu Not yet recruiting Cagliari, Italy, 09121 Contact: Maria Grazia Orofino, MD UOC Ematologia ed Oncologia Pediatrica con TMO AOU Policlinico Vittorio Emanuele Not yet recruiting Catania, Italy, 95123 Contact: Giovanna Russo, MD Reparto Trapianti Midollo Osseo Clinica Pediatrica Universitaria Fondazione MBBM-Ospedale San Gerardo Not yet recruiting Monza, Italy, 20900 Contact: Sonia Bonanomi, MD S.C. Oncoematologia Pediatrica Fondazione IRCCS Policlinico San Matteo Not yet recruiting Pavia, Italy, 27100 Contact: Marco Zecca, MD Oncoematologia Pediatrica A.O. di Perugia Ospedale S. Maria della Misericordia Not yet recruiting Perugia, Italy, 06156 Contact: Maurizio Caniglia, MD U.O. Oncoematologia Pediatrica Azienda Ospedaliero Universitaria Pisana Ospedale S. Chiara Not yet recruiting Pisa, Italy, 56100 Contact: Mariacristina Menconi, MD Ospedale Bambino Gesu Roma Recruiting Rome, Italy, 00165 Contact: Franco Locatelli, MD, Prof. Ospedale Infantile Regina Margherita Torino Recruiting Turin, Italy, 10126 Contact: Franca Fagioli, MD, Prof. U.O.C. Oncoematologia Pediatrica Policlinico "G.B. Rossi" - AOUI Verona Recruiting Verona, Italy, 37134 Contact: Simone Cesaro, MD Poland Szpital Uniwersytecki im. dr Antoniego Jurasza Recruiting Bydgoszcz, Poland, 85-094 Contact: Jan Styczynski, MD, Prof Uniwersytecki Szpital Dzieciecy w Krakowie Recruiting Krakow, Poland, 30-663 Contact: Jolanta Gozdzik, MD Dzieciecy Szpital Kliniczny im. A. Gebali w Lublinie Not yet recruiting Lublin, Poland, 20-093 Contact: Katarzyna Drabko, MD Wroclaw Medical University, Department of Pediatric Hematology/Oncology and BMT Recruiting Wroclaw, Poland, 50-368 Contact: Krzysztof Kałwak, MD, PhD, Prof. (48)-71 ext 7703170 收起 <<
NCT00919503	Hematopoietic Cell Transplanta... 展开 >>tion Recipient Non-Malignant 收起 <<	Phase 2	Recruiting	-	United States, Colorado ... 展开 >> Children's Hospital Colorado Active, not recruiting Aurora, Colorado, United States, 80045 United States, Oregon Oregon Health and Science University Completed Portland, Oregon, United States, 97239 United States, Tennessee Vanderbilt University/Ingram Cancer Center Active, not recruiting Nashville, Tennessee, United States, 37232 United States, Washington Seattle Children's Hospital Recruiting Seattle, Washington, United States, 98105 Contact: Lauri M. Burroughs 206-667-2396 lburroug@fhcrc.org Principal Investigator: Lauri M. Burroughs Fred Hutch/University of Washington Cancer Consortium Recruiting Seattle, Washington, United States, 98109 Contact: Lauri M. Burroughs 206-667-2396 lburroug@fhcrc.org Principal Investigator: Lauri M. Burroughs United States, Wisconsin Children's Hospital of Wisconsin Suspended Milwaukee, Wisconsin, United States, 53226 收起 <<
NCT01062490	Myelodysplastic Syndrome	Phase 2	Completed	-	Finland ... 展开 >> Helsinki University Central Hospital Helsinki, Finland, 00029 收起 <<
NCT01063647	Hematological Malignancies	Phase 1 Phase 2	Completed	-	Finland ... 展开 >> Helsinki University Central Hospital Helsinki, Finland, FIN-00290 Germany Charité University Hospital Berlin Berlin, Germany, 12203 University Hospital Hamburg Eppendorf Hamburg, Germany, 20246 5th Medical Clinic, Clinic North Nuremberg, Germany, 90340 University Hospital Rostock Rostock, Germany, 18057 Poland Silesian Medical University Katowice, Poland, 40-029 Sweden Karolinska University Hospital & Karolinska Institute Stockholm, Sweden, 141 86 收起 <<
NCT01063660	Acute Myeloid Leukaemia	Phase 2	Completed	-	Germany ... 展开 >> University of Rostock Rostock, Germany, 18057 收起 <<
NCT00491634	Acute Myeloid Leukemia ... 展开 >> Myelodysplastic Syndrome 收起 <<	Phase 2	Completed	-	Israel ... 展开 >> Chaim Sheba Medical Center Tel-Hashomer, Israel 收起 <<
NCT00598624	Leukemia Chro... 展开 >>nic Myeloid Leukemia Myelodysplastic Syndrome Diffuse Large Cell Lymphoma Hodgkin Lymphoma Chronic Lymphocytic Leukemia Multiple Myeloma 收起 <<	Phase 2	Unknown	December 2010	Italy ... 展开 >> Ematologia, Ospedale Casa Sollievo della Sofferenza Recruiting San Giovanni Rotondo, Foggia, Italy Contact: Angelo Michele Carella, MD am.carella@operapadrepio.it Contact: Marzia Tricarico, DM m.tricarico@operapadrepio.it Principal Investigator: Nicola Cascavilla, MD IRCCS San Raffaele; Unità Operativa di Ematologia Recruiting Milano, MI, Italy, 20100 Contact: Alessandro Crotta, MD +39 0226433903 a.crotta@hsr.it Contact: Stefania Trinca +39 0226434289 stefania.trinca@hsr.it Principal Investigator: Jacopo Peccatori, MD USC Ematologia, Ospedali Riuniti Recruiting Bergamo, Italy Contact: Anna Grassi, MD agrassi@ospedaliriuniti.bergamo.it Contact: Maria Luisa Ferrari, DM mlferrari@ospedaliriuniti.bergamo.it Principal Investigator: Alessandro Rambaldi, MD Ospedale centrale di Bolzano - Reparto di Ematologia Recruiting Bolzano, Italy Contact: Enrico Morello, MD +390471908807 enrico.morello@asbz.it Principal Investigator: Enrico Morello, MD PO "R.Binaghi" - CTMO Recruiting Cagliari, Italy Contact: Adriana Vacca, MD +393285452813 vaadriana@tiscali.it Principal Investigator: Giorgio La Nasa, MD AO "Santa Croce" e Carle - Reparto di Ematologia Recruiting Cuneo, Italy Contact: Laura Bertolotti, Data Manager +390171642229 laura.bertolotti@libero.it Principal Investigator: Andrea Gallamini, MD Istituto Europeo di Oncologia - Divisione di Ematologia Recruiting Milano, Italy Contact: Liliana Calabrese, Data Manager +390257489536 liliana.calabrese@ieo.it Principal Investigator: Giovanni Martinelli, MD Ospedale Civile - UTI ematologia per il trapianto emopoietico Recruiting Pescara, Italy Contact: Paolo Di Bartolomei, MD pescaratmo@virgilio.it Principal Investigator: Paolo Di Bartolomei, MD Arcispedale Santa Maria Nuova - SC di Ematologia Recruiting Reggio Emilia, Italy Contact: Alessandro Bonini, MD bonini.alessandro@asmn.re.it Principal Investigator: Luigi Gugliotta, MD Dipartimento Biotecnologie Cellulari ed Ematologia; Azienda Policlinico Umberto I Recruiting Roma, Italy, 00100 Contact: Emilia Iannella, MD +39 3202233365 emiliaiannella@libero.it Contact: Roberto Ricci +39 3477578735 r.ricci@bce.uniroma1.it Principal Investigator: Roberto Foa, MD AO San Camillo Forlanini - UOC ematologia e trapianto Recruiting Roma, Italy Contact: Beatrice Pinazzi, MD mpinazzi@scamilloforlanini.rm.it Principal Investigator: Ignazio Majolino, MD AOU Santa Maria della Misericordia - Clinica Ematologica Recruiting Udine, Italy Contact: Francesca Patriarca, MD patriarca.francesca@aoud.sanita.fvg.it Principal Investigator: Michela Cerno, MD 收起 <<
NCT01772953	Acute Myeloid Leukemia (AML) ... 展开 >> Myelodysplastic Syndrome (MDS) 收起 <<	Phase 2	Completed	-	-
NCT02048800	-		Unknown	March 2017	United Kingdom ... 展开 >> Great Ormond Street Hospital for Children Recruiting London, United Kingdom, WC1N 3JH Contact: Robert Chiesa, MD 02078138434 ext 8434 robert.chiesa@gosh.nhs.uk Contact: Praseeda Thaikaloor 02079052346 praseeda.thaikalloor@gosh.nhs.uk Great North Childrens Hospital Recruiting Newcastle Upon Tyne, United Kingdom, NE1 4LP Contact: Mary Slatter, MD 01912823767 mary.slatter@nuth.nhs.uk 收起 <<
NCT02333058	Acute Lymphoblastic Leukaemias... 展开 >> (ALL) Acute Myeloid Leukaemias (AML) Myelodysplastic Syndromes (MDS) Juvenile Myelomonocytic Leukaemias (JMML) 收起 <<	Phase 2	Active, not recruiting	September 2019	Austria ... 展开 >> St. Anna Children Hospital Vienna, Austria, A-1090 Czechia University Hospital Motol, Charles University, Prague Prague, Czechia, 150-06 Germany University Clinic Düsseldorf Düsseldorf, Germany, 40225 University Clinic Erlangen-Nürnberg Erlangen, Germany, 91054 University Hospital Johann Wolfgang Goethe Frankfurt, Germany, 60590 University Clinic Hamburg-Eppendorf Hamburg, Germany, 20246 Medical University Hannover Hannover, Germany, 30625 University Clinic Heidelberg Heidelberg, Germany, 69120 University Clinic Jena Jena, Germany, 07740 University Clinic München München, Germany, 80804 Univercity Clinic Münster Münster, Germany, 48129 University Clinic Regensburg Regensburg, Germany, 93053 University Clinic Ulm Ulm, Germany, 89075 University Clinic Würzburg Würzburg, Germany, 97080 Italy Ospedale Bambino Gesu Roma Rome, Italy, 00165 Ospedale Infantile Regina Margherita Torino Turin, Italy, 10126 Poland Bydgoszcz Medical University Bydgoszcz, Poland, 85-094 Kraków Medical University Kraków, Poland, 30-663 Lublin Medical University Lublin, Poland, 20-093 Wroclaw Medical University Wroclaw, Poland, 50-368 United Kingdom Birmingham Children's Hospital Birmingham, United Kingdom, B4 6NH Central Manchester University Hospital Manchester, United Kingdom, M13 9WL Sheffield Children's Hospital Sheffield, United Kingdom, S10 2TH 收起 <<

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