Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties.
规格 | 价格 | 会员价 | 库存 | 数量 | |||
---|---|---|---|---|---|---|---|
{[ item.pr_size ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
产品名称 | Potassium Channel ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tolbutamide | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Glimepiride |
++++
SUR2B, IC50: 7.3 nM SUR1, IC50: 5.4 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Dronedarone Hydrochloride | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Gliquidone |
++
Potassium channel, IC50: 27.2 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
TRAM-34 |
+++
IKCa1 (KCa3.1), Kd: 20 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Glibenclamide | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Amiodarone HCl | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Gliclazide |
++
Potassium channel, IC50: 184 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Repaglinide | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Dofetilide | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Nateglinide | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Quinine hydrochloride dihydrate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
ML133 HCl |
+
Kir2.1, IC50: 290 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Tetraethylammonium chloride is recognized as a non-selective blocker of potassium channels and is also an effective substrate for the organic cation transporter (OCTN1). It exhibits notable antitumor properties[1].[2]. |
体内研究 | Further research indicates that Tetraethylammonium at concentrations of 1 mM, 3 mM, and 5 mM significantly enhances the amplitude and frequency of contractility in the colon and rectum of rats, both in longitudinal and circular directions. It was also found that Tetraethylammonium at 5 mM and 15 mM does not affect the histology of the colon and rectum when administered locally into the colon lumen from the anus for 10 days[2]. |
体外研究 | In studies involving C6 and 9L glioma cells, treatment with Tetraethylammonium chloride ranging from 0.2 to 60 mM over 24 to 72 hours inhibits cell proliferation in a dose- and time-dependent manner[1]. At a concentration of 40 mM applied over 24 to 72 hours, this treatment significantly increases apoptosis in these cells[1]. Additionally, the same treatment at 40 mM for 12 to 48 hours significantly elevates the Bax/Bcl-2 protein ratio, indicating an increase in pro-apoptotic signaling in a time-dependent manner[1]. The generation of intracellular reactive oxygen species (ROS) is increased in C6 and 9L cells with the addition of 20 and 40 mM Tetraethylammonium[1]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
6.03mL 1.21mL 0.60mL |
30.17mL 6.03mL 3.02mL |
60.35mL 12.07mL 6.03mL |
CAS号 | 56-34-8 |
分子式 | C8H20ClN |
分子量 | 165.704 |
别名 | TEA chloride |
运输 | 蓝冰 |
存储条件 |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(633.66 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 100 mg/mL(603.49 mM) |
动物实验配方 |