Telotristat ethyl (15, 50, 150, 300 mg/kg, po, qd) lowers serotonin levels in the peripheral tissues without affecting brain serotonin in mice. At a dosage of 200 mg/kg once daily, it blocks the rise in blood neutrophil counts triggered by TNBS, offering considerable protection in a mouse model of inflammatory bowel disease. This protective effect of Telotristat ethyl at 200 mg/kg daily in the IBD mouse model is verified through histopathological assessment^[1].

Telotristat ethyl (15, 50, 150, 300 mg/kg) depletes serotonin (5-HT) in the jejunum but not the brain. And Telotristat ethyl (200 mg/kg, Po.). does not deplete intestinal neuronal serotonin and does not alter structural gastrointestinal motility in mice. Tiratriptan ethyl (200 mg/kg) attenuates the severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis^[2].