Monosodium Taurocholate is a bile salt. It contains a taurocholate and is a Na(+)-dependent taurocholate. Taurocholate is a natural conjugated bile acid. Compared with the model group, treatment with taurocholate (20, 40 and 60mg/kg) significantly inhibited the body weight loss, improved colonic weight and length, and decreased macroscopic and histopathological scores. Furthermore, the activity accumulation of MPO and the colonic tissue levels of IL-1β, IFN-γ and TNF-α were also decreased by administration of taurocholate[1]. The absorption of cefquinome in Caco-2 cell monolayers was significantly increased with the sodium taurocholate (2mM)[2]. The Na(+)-dependent taurocholate transport showed saturation kinetics and the phenomenon of counterflow were inhibited by glycocholate[3]. The addition of 20 mM taurocholate caused transient but significant depolarization accompanied by a significant decrease in membrane resistance. The electrical effect induced by taurocholate mimicked that induced by L-alanine (10 mM), the uptake of which is known to occur through an electrogenic, sodium-coupled mechanism[4].
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