产品说明书
Taurocholic acid sodium
 |
同义名 : | Sodium taurocholate;N-Choloyltaurine sodium;TCA;Ethanesulfonic Acid;Taurocholic Acid (sodium salt);TANa;Taurocholic acid sodium salt |
| CAS号 : | 145-42-6 | |
| 货号 : | A198685 | |
| 分子式 : | C26H44NNaO7S | |
| 纯度 : | 98% | |
| 分子量 : | 537.685 | |
| MDL号 : | MFCD00150819 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 250 mg/mL(464.96 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(185.98 mM)，配合低频超声助溶 |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Monosodium Taurocholate is a bile salt. It contains a taurocholate and is a Na(+)-dependent taurocholate. Taurocholate is a natural conjugated bile acid. Compared with the model group, treatment with taurocholate (20, 40 and 60mg/kg) significantly inhibited the body weight loss, improved colonic weight and length, and decreased macroscopic and histopathological scores. Furthermore, the activity accumulation of MPO and the colonic tissue levels of IL-1β, IFN-γ and TNF-α were also decreased by administration of taurocholate[1]. The absorption of cefquinome in Caco-2 cell monolayers was significantly increased with the sodium taurocholate (2mM)[2]. The Na(+)-dependent taurocholate transport showed saturation kinetics and the phenomenon of counterflow were inhibited by glycocholate[3]. The addition of 20 mM taurocholate caused transient but significant depolarization accompanied by a significant decrease in membrane resistance. The electrical effect induced by taurocholate mimicked that induced by L-alanine (10 mM), the uptake of which is known to occur through an electrogenic, sodium-coupled mechanism[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.86mL 0.37mL 0.19mL |
9.30mL 1.86mL 0.93mL |
18.60mL 3.72mL 1.86mL |
| 参考文献 |
|---|