There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
TUG-424 is a potent and selective agonist of the free fatty acid receptor 1 (FFA1/GPR40) with an EC50 of 32 nM. It significantly enhances glucose-stimulated insulin secretion at 100 nM and may be useful for researching the role of FFA1 in metabolic diseases such as diabetes or obesity[1]. TUG-424 is a click chemistry reagent that features an alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that possess azide groups.
体外研究
TUG-424, at concentrations ranging from 100 nM to 10 µM, significantly enhances glucose-stimulated insulin secretion starting at 100 nM, reaching a peak effect at 3 µM. This approximately two-fold increase in secretion in the presence of 12 mM glucose is similar to the effect seen with palmitate at the same glucose level. At a basal glucose concentration of 2.8 mM, TUG-424 slightly but significantly decreases insulin secretion[1].
搜索
HazMat Fee +
