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TUG-424

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Chemical Structure| 1082058-99-8 同义名 : CAY10587
CAS号 : 1082058-99-8
货号 : A379536
分子式 : C18H16O2
纯度 : 99%+
分子量 : 264.318
MDL号 : MFCD12912449
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 TUG-424 is a potent and selective agonist of the free fatty acid receptor 1 (FFA1/GPR40) with an EC50 of 32 nM. It significantly enhances glucose-stimulated insulin secretion at 100 nM and may be useful for researching the role of FFA1 in metabolic diseases such as diabetes or obesity[1]. TUG-424 is a click chemistry reagent that features an alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that possess azide groups.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.78mL

0.76mL

0.38mL

18.92mL

3.78mL

1.89mL

37.83mL

7.57mL

3.78mL
参考文献

[1]Discovery of Potent and Selective Agonists for the Free Fatty Acid Receptor 1 (FFA1/GPR40), a Potential Target for the Treatment of Type II Diabetes J. Med. Chem., 2008, 51 (22), pp 7061-7064