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首页 / 抑制剂/激动剂 / G蛋白偶联受体/G蛋白 / PAR / TRAP-6

TRAP-6 {[allProObj[0].p_purity_real_show]}

货号：A693456 同义名： PAR-1 agonist peptide;Thrombin Receptor Activator Peptide 6

TRAP-6 (PAR1激动肽)是一种多肽片段，是一种选择性蛋白酶激活受体1 (PAR1)激动剂。TRAP-6通过凝血酶受体激活人血小板。TRAP-6对PAR4无效。

TRAP-6 化学结构 CAS号：141136-83-6
TRAP-6 化学结构
CAS号：141136-83-6
TRAP-6 3D分子结构
CAS号：141136-83-6
TRAP-6 化学结构 CAS号：141136-83-6
TRAP-6 3D分子结构 CAS号：141136-83-6
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TRAP-6 纯度/质量文件 产品仅供科研

货号：A693456 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]
• JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]
• BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]
• J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]
• PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]
更多 >

TRAP-6 生物活性

描述 Proteinase-activated receptors (PARs) represent a unique subclass of G-protein-coupled receptors of which four family members have now been cloned from a number of species[3]. PAR1 has been implicated as a key mediator in cellular functions and is activated by the PAR1 agonist, thrombin, as well as by serine proteases. TRAP-6 is a PAR1 agonist[2]. Adenosine 5′-diphosphate (ADP) inducible aggregation which is used to assess platelet response to thienopyridines was correlated to that by TRAP-6 (r = 0.33 to 0.72; p < 0.001 for all assays)[4]. In platelet-rich plasma (PRP) of patients (n = 34) with unexplained venous thromboembolism, platelet aggregometry was performed and the influence of TRAP-6 was determined. Compared to the control group, patients with venous thromboembolism showed an enhanced maximal platelet aggregation with low concentrations of TRAP-6 (2 μM)[5].

TRAP-6 参考文献

[1]Mitrugno A, Rigg RA, et al. Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y(12) signaling with MRS2395. Platelets. 2017 May 19:1-12.

[2]Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells

[3]International Union of Pharmacology. XXVIII. Proteinase-activated receptors

[4]Is TRAP-6 suitable as a positive control for platelet reactivity when assessing response to clopidogrel?

[5] Enhanced platelet aggregation with TRAP-6 and collagen in platelet aggregometry in patients with venous thromboembolism

TRAP-6 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.34mL

0.27mL

0.13mL

6.68mL

1.34mL

0.67mL

13.35mL

2.67mL

1.34mL

TRAP-6 技术信息

CAS号141136-83-6
分子式C34H56N10O9
分子量 748.87
别名 PAR-1 agonist peptide;Thrombin Receptor Activator Peptide 6;Ser-Phe-Leu-Leu-Arg-Asn;SFLLRN-OH;SFLLRN
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C
溶解度

H2O: 25 mg/mL(33.38 mM)，配合低频超声助溶
动物实验配方

Tags: TRAP-6 | 141136-83-6 | PAR-1 agonist peptide | Thrombin Receptor Activator Peptide 6 | TRAP6 | TRAP 6 | Thrombin Receptor Activator Peptide6 | Thrombin Receptor Activator Peptide 6 | Thrombin Receptor Activator Peptide-6 | PAR1 Agonist | GPCR/G Protein | Protease Activated Receptor (PAR) | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | TRAP-6 纯度/质量文件 | TRAP-6 生物活性 | TRAP-6 参考文献 | TRAP-6 实验方案 | TRAP-6 技术信息

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