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TRAP-6

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Chemical Structure| 141136-83-6 同义名 : PAR-1 agonist peptide;Thrombin Receptor Activator Peptide 6;Ser-Phe-Leu-Leu-Arg-Asn;SFLLRN-OH;SFLLRN
CAS号 : 141136-83-6
货号 : A693456
分子式 : C34H56N10O9
纯度 : 99%+
分子量 : 748.87
MDL号 : MFCD00238172
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 25 mg/mL(33.38 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Proteinase-activated receptors (PARs) represent a unique subclass of G-protein-coupled receptors of which four family members have now been cloned from a number of species[3]. PAR1 has been implicated as a key mediator in cellular functions and is activated by the PAR1 agonist, thrombin, as well as by serine proteases. TRAP-6 is a PAR1 agonist[2]. Adenosine 5′-diphosphate (ADP) inducible aggregation which is used to assess platelet response to thienopyridines was correlated to that by TRAP-6 (r = 0.33 to 0.72; p < 0.001 for all assays)[4]. In platelet-rich plasma (PRP) of patients (n = 34) with unexplained venous thromboembolism, platelet aggregometry was performed and the influence of TRAP-6 was determined. Compared to the control group, patients with venous thromboembolism showed an enhanced maximal platelet aggregation with low concentrations of TRAP-6 (2 μM)[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.34mL

0.27mL

0.13mL

6.68mL

1.34mL

0.67mL

13.35mL

2.67mL

1.34mL
参考文献

[1]Mitrugno A, Rigg RA, et al. Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y(12) signaling with MRS2395. Platelets. 2017 May 19:1-12.

[2]Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells

[3]International Union of Pharmacology. XXVIII. Proteinase-activated receptors

[4]Is TRAP-6 suitable as a positive control for platelet reactivity when assessing response to clopidogrel?

[5] Enhanced platelet aggregation with TRAP-6 and collagen in platelet aggregometry in patients with venous thromboembolism