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Suramin sodium salt

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Chemical Structure| 129-46-4 同义名 : 苏拉明钠盐 ;Suramin hexasodium salt;Suramin Sodium;NF 060;Germanin;BAY 205;Suramin (sodium salt)
CAS号 : 129-46-4
货号 : A397022
分子式 : C51H34N6Na6O23S6
纯度 : 99%+
分子量 : 1429.171
MDL号 : MFCD00210217
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(59.48 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(34.99 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • SIRT1

    SirT1, IC50:297 nM

  • SIRT5

    SirT5, IC50:22 μM

  • RdRp

    RdRp, IC50:0.26 μM
描述 Suramin sodium salt is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 = 4.9 μM), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors(10-100 μM).
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00001230 - Recruiting - United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)    800-441-1222 ext TTY8864111010    prpl@cc.nih.gov 收起 <<
NCT02347332 Recurrent or Metastatic Head a... 展开 >>nd Neck Carcinoma 收起 << Phase 3 Active, not recruiting June 2018 -
NCT02871284 Exercise Chem... 展开 >>otherapy-induced Polyneuropathy 收起 << Phase 2 Phase 3 Recruiting December 2019 Germany ... 展开 >> National Center for Tumor Diseases Recruiting Heidelberg, Germany, 69120 Contact: Joachim Wiskemann, Dr.       joachim.wiskemann@nct-heidelberg.de    Contact: Jana Müller       jana.mueller@nct-heidelberg.de 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.70mL

0.14mL

0.07mL

3.50mL

0.70mL

0.35mL

7.00mL

1.40mL

0.70mL
参考文献

[1]Nautiyal A, Patil KN, et al. Suramin is a potent and selective inhibitor of Mycobacterium tuberculosis RecA protein and the SOS response: RecA as a potential target for antibacterial drug discovery. J Antimicrob Chemother. 2014 Jul;69(7):1834-43.

[2]Jindal HK, Anderson CW, et al. Suramin affects DNA synthesis in HeLa cells by inhibition of DNA polymerases. Cancer Res. 1990 Dec 15;50(24):7754-7.