Sulfadoxine is a long-lasting sulfonamide that is usually used in combination with other drugs, for respiratory, urinary tract and malarial infections.
Sulfadoxine is predominantly used in combination with pyrimethamine, commonly known as Fansidar, for the treatment of Plasmodium falciparum. This combination is usually less effective against Plasmodium vivax, probably due to the innate refractoriness of parasites to the sulfadoxine component[2]. Sulfadoxine/pyrimethamine is recommended for intermittent preventative treatment of malaria during pregnancy. During pregnancy, clearance increased 3-fold for sulfadoxine but decreased by 18% for pyrimethamine. Postpartum sulfadoxine clearance decreased gradually over 13 weeks[3]. HIV-infected (HIV(+)) women require more frequent doses of intermittent preventive therapy with SP (Sulfadoxine-pyrimethamine) than do HIV-uninfected (HIV(-)) women. Pregnancy significantly modifies the disposition of SP, whereas HIV status has little influence on pharmacokinetic parameters in pregnant women[4]. SP was associated with a reduced risk of LBW (low birth weight) in HIV-positive women, including those receiving ART, in a low malaria prevalence region[5].
Sierra Leone
... 展开 >> 1 Moriba Street
Recruiting
Pujehun, Pujehun District, Sierra Leone
Contact: Claire Westcott, PA +232-88-111-007
Sub-Investigator: David T Hendrixson, MD
Sub-Investigator: Aminata Koroma 收起 <<
Nigeria
... 展开 >> Damboa Hospital Borno state and Park Lane hospital Enugu state
Recruiting
Enugu,, borno State and Enugu state, Nigeria
Contact: Elvis N Shu Cell: + 234 803 317 0257 shuneba@gmail.com
Principal Investigator: Elvis Shu 收起 <<
Burkina Faso
... 展开 >> Université de Ouagadougou
Ouagadougou, Burkina Faso
Gambia
Medical Research Council Laboratories
Basse, Gambia
Ghana
Navrongo Health Research Centre
Navrongo, Ghana
Mali
Medical Research and Training Centre
Bamako, Mali 收起 <<
Mozambique
... 展开 >> Bela Vista Clinic
Bela Vista, Matutuine, Mozambique
Namaacha Clinic
Namaacha, Mozambique
South Africa
Ndumo Clinic
Ndumo, KwaZulu Natal, South Africa
Lulekani Clinic
Lulekani, Limpopo, South Africa
Naas Clinic
Naas, Mpumalanga, South Africa
Swaziland
Ndzevane Clinic
Ndzevane, Swaziland
Vuvulane Clinic
Vuvulane, Swaziland 收起 <<
Tanzania
... 展开 >> Kibaoni Health Centre
Ifakara, Kilombero District, Tanzania
St Francis Designated District Hospital
Ifakara, Kilombero District, Tanzania 收起 <<
Malaria in Pregnancy
... 展开 >> HIV Infection 收起 <<
Phase 3
Unknown
-
Central African Republic
... 展开 >>
Maternité de l'Hôpital communautaire
Not yet recruiting
Bangui, Central African Republic
Maternité de l'Hôpital de l'Amitié
Not yet recruiting
Bangui, Central African Republic
Maternité de la Gendarmerie Nationale
Not yet recruiting
Bangui, Central African Republic
Maternité du centre de santé des Castors
Not yet recruiting
Bangui, Central African Republic 收起 <<
Pregnancy
Mal... 展开 >>aria in Pregnancy
Malaria 收起 <<
Phase 3
Not yet recruiting
October 2019
Kenya
... 展开 >> Ahero Sud-countyHospital
Not yet recruiting
Ahero, Kisumu, Kenya
Contact: Simon Kariuki, PhD + 254725389246 SKariuki@kemricdc.org
Homa Bay County Hospital
Not yet recruiting
Homa Bay, Kenya
Contact: Simon Kariuki, PhD + 254725389246 SKariuki@kemricdc.org
Rabour Sub-county Hospital
Not yet recruiting
Kisumu, Kenya
Contact: Simon Kariuki, PhD + 254725389246 SKariuki@kemricdc.org
Malawi
Chikwawa District Hospital
Not yet recruiting
Chikwawa, Malawi
Contact: Victor Mwapasa, PhD +265999981496 vmwapasa@gmail.com
Mangochi District Hospital
Not yet recruiting
Mangochi, Malawi
Contact: Kenneth Maleta, PhD +265888232202 ken.maleta@gmail.com
Tanzania
Handeni District Hospital
Handeni, Tanzania
Korogwe District Hospital
Korogwe, Tanzania 收起 <<
Tanzania
... 展开 >> National Institute for Medical Research
Not yet recruiting
Tanga, Tanzania, 255
Contact: Centre Director +255272646084 tanga@nimr.or.tz
Contact: Vito Baraka, PhD +255715380010 vitobaraka@gmail.com
Principal Investigator: Geofrey Makenga, MD, MSc
Sub-Investigator: Vito Baraka, PhD
Sub-Investigator: Filbert Fransis, MSc
Sub-Investigator: Rashid Madebe, MSc
Sub-Investigator: Edwin Liheluka, MSc 收起 <<
Tanzania
... 展开 >> Ngere Ngere Health Center
Ngere Ngere, Morogoro Rural, Tanzania
Ikwiriri Health Center
Ikwiriri, Rufiji, Tanzania
Lupiro Health Center
Lupiro, Ulanga, Tanzania 收起 <<
India
... 展开 >> Pfizer Investigational Site
Dispur Guwahati, Assam, India, 781006
Pfizer Investigational Site
Bambolim, Gao, India, 403002
Pfizer Investigational Site
Nagpur, Maharashtra, India, 440 018
Pfizer Investigational Site
Parel Mumbai, Maharashtra, India, 400012
Pfizer Investigational Site
Rourkela, Orissa, India, 769005
Pfizer Investigational Site
Vellore, Tamil Nadu, India, 632 004
Pfizer Investigational Site
Indore, India, 452001 收起 <<
Terminated(Low prevalence of m... 展开 >>alaria, high prevalence of reported allergy to sulphur drugs, high proportion of women not meeting the inclusion criterea.) 收起 <<
August 2010
Solomon Islands
... 展开 >>
Honiara City Council
Honiara, Solomon Islands 收起 <<
Philippines
... 展开 >> Kalinga Health Center
Tabuk, Kalinga Province, Philippines
Davao Health Center
Davao City, Mindinao, Philippines
Palawan Health Center
Puerto Princesa, Palawan, Philippines 收起 <<
Intermittent Preventive Treatm... 展开 >>ent In Pregnancy (IPTp) 收起 <<
Phase 3
Terminated(See termination rea... 展开 >>son in detailed description.) 收起 <<
-
Benin
... 展开 >> Centre de Santé d'AHOUANSORI-AGUE
Cotonou, Benin
Hôpital Bethesda
Cotonou, Benin
Kenya
Siaya District Hospital
Siaya, Kenya
Malawi
Zomba Central Hospital
Zomba, Malawi
Tanzania
Teule Hospital
Muheza, Tanga, Tanzania
Bugando Medical Centre
Mwanza, Tanzania, 1903
Nyamagana District Hospital, c/o National Institute for Medical Research, Mwanza Centre
Mwanza, Tanzania
Nyamagana District Hospital
Mwanza, Tanzania
Uganda
Mulago Hospital Complex
Kampala, Uganda 收起 <<
Terminated(The study was termi... 展开 >>nated because of Early Treatment Failure in child.The justification for this decision are concerns about safety of children.) 收起 <<
-
Gabon
... 展开 >> Medical Research Unit of the Albert Schweitzer Hospital
Lambaréné, Moyen Ogooué, Gabon, B.P. 118 收起 <<
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