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硫酸链霉素 /Streptomycin sulfate {[allProObj[0].p_purity_real_show]}

货号:A172127 同义名: Streptomycin (sulfate);Phytomycin

Streptomycin Sulfate is a broad-spectrum aminoglycoside antibiotic used to treat a number of bacterial infections, acting by binding to the 30S ribosomal subunit of susceptible organisms and disrupting the initiation and elongation steps in protein synthesis.

Streptomycin sulfate 化学结构 CAS号:3810-74-0
Streptomycin sulfate 化学结构
CAS号:3810-74-0
Streptomycin sulfate 3D分子结构
CAS号:3810-74-0
Streptomycin sulfate 化学结构 CAS号:3810-74-0
Streptomycin sulfate 3D分子结构 CAS号:3810-74-0
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Streptomycin sulfate 纯度/质量文件 产品仅供科研

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Streptomycin sulfate 生物活性

描述 Streptomycin sulfate is an aminoglycoside antibiotic that inhibits protein synthesis. Most patients with bilateral Meniere's disease treated with streptomycin sulfate titration therapy and followed over the long term have either improvement or relief of their disabling vertigo[3]. Animal experiments have demonstrated severe damage to the vestibular hair cells after streptomycin treatment. The morphologic changes indicated that streptomycin damaged the cytoplasmic granules and the plasma membrane infoldings of the dark cells[4]. A case of community-acquired endocarditis caused by Enterococcus (Streptococcus) faecalis with high-level resistance to gentamicin sulfate but not to streptomycin sulfate is described[5].

Streptomycin sulfate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01432925 Mycobacterium Ulcerans Disease... 展开 >> Buruli Ulcer 收起 << Not Applicable Unknown - Benin ... 展开 >> Buruli ulcer center Allada Allada, Benin Buruli ulcer center Lalo Lalo, Benin 收起 <<
NCT00023374 Tuberculosis Not Applicable Completed - -
NCT00495326 Tuberculosis ... 展开 >>Aids Hiv Infections 收起 << Phase 2 Phase 3 Completed - Mozambique ... 展开 >> Health centre of Alto Mae, Chamanculo district Maputo, Mozambique Health centre of Josue Macao Maputo, Mozambique Health centre of Malavane Maputo, Mozambique 收起 <<

Streptomycin sulfate 参考文献

[1]Sharma D, Cukras AR, et al. Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome. J Mol Biol. 2007 Dec 7;374(4):1065-76. Epub 2007 Oct 6.

[2]McEnroe AS, Taber HW. Correlation between cytochrome aa3 concentrations and streptomycin accumulation in Bacillus subtilis. Antimicrob Agents Chemother. 1984 Oct;26(4):507-12.

[3]Graham MD. Bilateral Meniere's disease. Treatment with intramuscular titration streptomycin sulfate. Otolaryngol Clin North Am. 1997;30(6):1097–1100

[4]Ge X, Shea JJ. Intramuscular streptomycin effect on dark cells of utricle in guinea pigs. Am J Otol. 1993;14(1):74–78

[5]Spiegel CA, Huycke M. Endocarditis due to streptomycin-susceptible Enterococcus faecalis with high-level gentamicin resistance. Arch Intern Med. 1989;149(8):1873–1875

Streptomycin sulfate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.69mL

0.14mL

0.07mL

3.43mL

0.69mL

0.34mL

6.86mL

1.37mL

0.69mL

Streptomycin sulfate 技术信息

CAS号3810-74-0
分子式C42H84N14O36S3
分子量 1457.38
别名 Streptomycin (sulfate);Phytomycin
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C

溶解度

H2O: 100 mg/mL(68.62 mM)

动物实验配方
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