There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Sinomenine, a nature compound existing in sinomenium acutum, has many biological activity, such as anti-cancer activity. In vitro studies, sinomenine HCl could inhibit the growth, migration, invasiveness and angiogenesis in clear-cell renal cell carcinoma cells[1]. Besides this, it was found that sinomenium acutum could also suppress the viability of U87 and SF767 cell, through ROS generation and autophagy-lysosome pathway activation[2]. In vivo studies, sinomenine HCl has the ability of improving survival, reducing organ damage and attenuating the release of inflammatory cytokines in BALB/c mice with sepsis induced by cecal ligation and puncture (CLP), partially by regulating autophagy activities[3]. In addition, sinomenine HCl could contribute to the improvement of some clinical symptoms in rat model of renal fibrosis, induced by adriamycin[4].
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