Sinomenine

产品说明书

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Chemical Structure| 115-53-7 同义名 : Cucoline;Kukoline
CAS号 : 115-53-7
货号 : A296950
分子式 : C19H23NO4
纯度 : 98+%
分子量 : 329.39
MDL号 : MFCD00134303
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(151.8 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

1M HCl: 25 mg/mL(75.9 mM)，配合低频超声，并调节pH至1
动物实验配方：
生物活性
描述 Sinomenine, a nature compound existing in sinomenium acutum, has many biological activity, such as anti-cancer activity. In vitro studies, sinomenine HCl could inhibit the growth, migration, invasiveness and angiogenesis in clear-cell renal cell carcinoma cells[1]. Besides this, it was found that sinomenium acutum could also suppress the viability of U87 and SF767 cell, through ROS generation and autophagy-lysosome pathway activation[2]. In vivo studies, sinomenine HCl has the ability of improving survival, reducing organ damage and attenuating the release of inflammatory cytokines in BALB/c mice with sepsis induced by cecal ligation and puncture (CLP), partially by regulating autophagy activities[3]. In addition, sinomenine HCl could contribute to the improvement of some clinical symptoms in rat model of renal fibrosis, induced by adriamycin[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.04mL

0.61mL

0.30mL

15.18mL

3.04mL

1.52mL

30.36mL

6.07mL

3.04mL
参考文献

[1]Zhao B, Liu L, et al. Sinomenine hydrochloride attenuates the proliferation, migration, invasiveness, angiogenesis and epithelial-mesenchymal transition of clear-cell renal cell carcinoma cells via targeting Smad in vitro. Biomed Pharmacother. 2017.

[2]Jiang Y, Jiao Y, et al. Sinomenine Hydrochloride Inhibits Human Glioblastoma Cell Growth through Reactive Oxygen Species Generation and Autophagy-Lysosome Pathway Activation: An In Vitro and In Vivo Study. Int J Mol Sci. 2017;18(9).

[3]Jiang Y, Gao M, et al. Sinomenine hydrochloride protects against polymicrobial sepsis via autophagy. Int J Mol Sci. 2015;16(2):2559-73.

[4]Zhao MM, Yang B, et al. Sinomenine Hydrochloride Attenuates Renal Fibrosis by Inhibiting Excessive Autophagy Induced by Adriamycin: An Experimental Study. Evid Based Complement Alternat Med. 2017.