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Sinefungin {[allProObj[0].p_purity_real_show]}

货号:A713137 同义名: Antibiotic 32232RP;A-9145

Sinefungin is an inhibitor of Zika virus methyltransferase.

Sinefungin 化学结构 CAS号:58944-73-3
Sinefungin 化学结构
CAS号:58944-73-3
Sinefungin 3D分子结构
CAS号:58944-73-3
Sinefungin 化学结构 CAS号:58944-73-3
Sinefungin 3D分子结构 CAS号:58944-73-3
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Sinefungin 纯度/质量文件 产品仅供科研

货号:A713137 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 Histone Methyltransferase 其他靶点 纯度
BRD4770 99%+
UNC1999 +++

EZH2, IC50: 2 nM

EZH1, IC50: 45 nM

99%+
EPZ005687 ++

EZH2, Ki: 24 nM

98+%
EPZ015666 +++

PRMT5, Ki: 5 nM

99%+
3-Deazaneplanocin A HCl ++++

S-adenosylhomocysteine hydrolase, Ki: 50 pM

99%+
Tazemetostat +++

EZH2, IC50: 11 nM

EZH2, Ki: 2.5 nM

98%
GSK126 ++

EZH2, IC50: 9.9 nM

99%+
MI-3 +

Menin-MLL, IC50: 648 nM

98%
MM-102 ++

MLL1, IC50: 0.4 μM

99%
EI1 ++

EZH2 (Y641F), IC50: 13 nM

Ezh2 (wild-type), IC50: 15 nM

98%
SGC0946 ++++

DOT1L, IC50: 0.3 nM

99%+
PFI-2 HCl ++++

SETD7, Ki: 0.33 nM

SETD7, IC50: 2 nM

99%+
Pinometostat ++++

DOT1L, Ki: 80 pM

99%+
EPZ004777 +++

DOT1L, IC50: 0.4 nM

99%+
Entacapone ++

COMT, IC50: 151 nM

95%
UNC0379 +

SETD8, IC50: 7.9 μM

99%+
Menin-MLL inhibitor MI-2 +

Menin-MLL, IC50: 446 nM

98%
GSK343 +++

EZH2, IC50: 4 nM

EZH1, IC50: 240 nM

99%+
BIX-01294 3HCl +

G9a, IC50: 2.7 μM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Sinefungin 生物活性

描述 Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase and viral proliferation [1].Sinefungin is an SET7/9 inhibitor that ameliorates renal fibrosis by inhibiting H3K4 methylation[2].Treatment of cells with Sinefungin at concentrations of 0.5 or 1.0 μg/mL for 60 min ameliorated TGF-β1-induced increases in α-SMA and inhibited the up-regulation of histone H3K4 monomethylation in renal epithelial cells and renal fibroblasts[2].

Sinefungin 动物研究

Animal study Daily administration of Sinefungin at a dose of 10 mg/kg to animals after induction of the Unilateral Ureteral Obstruction model improved renal fibrosis in obstructive nephropathy[2].

Sinefungin 参考文献

[1]Pugh CS, et al. Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. J Biol Chem. 1978 Jun 25;253(12):4075-7.

[2]Sasaki K, et al. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis. J Am Soc Nephrol. 2016 Jan;27(1):203-15.

Sinefungin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.62mL

0.52mL

0.26mL

13.11mL

2.62mL

1.31mL

26.22mL

5.24mL

2.62mL

Sinefungin 技术信息

CAS号58944-73-3
分子式C15H23N7O5
分子量 381.387
别名 Antibiotic 32232RP;A-9145;RP 32232;Antibiotic A 9145;Adenosyl-Ornithine
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C

溶解度

H2O: 100 mg/mL(262.2 mM),配合低频超声助溶

动物实验配方
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