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Sinefungin

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Chemical Structure| 58944-73-3 同义名 : Antibiotic 32232RP;A-9145;RP 32232;Antibiotic A 9145;Adenosyl-Ornithine
CAS号 : 58944-73-3
货号 : A713137
分子式 : C15H23N7O5
纯度 : 99%+
分子量 : 381.387
MDL号 : MFCD00865623
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 100 mg/mL(262.2 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase and viral proliferation [1].Sinefungin is an SET7/9 inhibitor that ameliorates renal fibrosis by inhibiting H3K4 methylation[2].Treatment of cells with Sinefungin at concentrations of 0.5 or 1.0 μg/mL for 60 min ameliorated TGF-β1-induced increases in α-SMA and inhibited the up-regulation of histone H3K4 monomethylation in renal epithelial cells and renal fibroblasts[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.62mL

0.52mL

0.26mL

13.11mL

2.62mL

1.31mL

26.22mL

5.24mL

2.62mL
参考文献

[1]Pugh CS, et al. Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. J Biol Chem. 1978 Jun 25;253(12):4075-7.

[2]Sasaki K, et al. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis. J Am Soc Nephrol. 2016 Jan;27(1):203-15.