Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist.
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HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
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Accessible (Haz class 3, 4, 5 or 8), International
Thromboxane synthase (TXAS) is a P450 epoxygenase that synthesizes thromboxane A2 (TXA2), a potent mediator of platelet aggregation, vasoconstriction and bronchoconstriction[3]. Seratrodast (AA 2414) is an anti-asthmatic agent and a potent and selective thromboxane A2 receptor (TP) antagonist[4]. Seratrodast inhibited peroxide-induced vasoconstriction in the human placenta, as well as peroxide- induced increases in the placental secretion rates of lipid peroxides and thromboxane, but only partially inhibited peroxide-induced increases in the placental secretion rate of prostacyclin[5]. Seratrodast reduced the overproduction of TxB2 in both bronchoalveolar lavage fluid and lung tissues. Cigarette smoke exposure markedly increased AB/PAS-stained goblet cells and rat Muc5ac expression in the airway, which was significantly attenuated by seratrodast administration. The induced phosphorylation of ERK and p38 was also attenuated by seratrodast[6]. The anti-asthmatic activity of AA-2414 has been studied in vivo and in vitro. Experimental allergic asthma was inhibited by orally administered AA-2414 in a dose-dependent manner. AA-2414, 0.08-1.25 mg/kg (p.o.), inhibited the bronchconstriction in guinea pigs induced by a prostaglandin endoperoxide analogue (U-46619), leukotriene D4 (LTD4), and platelet activating factor (PAF) with a long duration of action. The compound did not inhibit histamine-induced bronchoconstriction. AA-2414 reduced the induction of pulmonary inflation caused by LTD4 aerosol inhalation. AA-2414 competitively inhibited the contractile response to U-46619 in guinea pig tracheal and parenchymal strips and dog saphenous vein strips with pA2 values of 7.69, 8.29 and 6.79, respectively[7].
Mucopolysaccharidosis Type 3 A... 展开 >> Sanfilippo Syndrome 收起 <<
Phase 1
Phase 2
Recruiting
December 2020
United States, Ohio
... 展开 >>
Nationwide Children's Hospital
Recruiting
Columbus, Ohio, United States, 43205
Contact: Krista Kunkler 614-722-2238 krista.kunkler@nationwidechildrens.org
Australia, South Australia
Women's and Children's Hospital
Recruiting
North Adelaide, South Australia, Australia, 5006
Contact: Louise Jaensch 08 8161 7295 louise.jaensch@sa.gov.au
Principal Investigator: Nicholas Smith, MD
Spain
Hospital Clínico Universitario de Santiago
Recruiting
Santiago De Compostela, Spain, 15706
Contact: Maria Luz Couce, MD +34 981 950 151 maria.luz.couce.pico@sergas.es
Contact: Maria Jose de Castro, MD +34 981 955 627 maria.jose.de.castro.lopez@sergas.es 收起 <<
Mucopolysaccharidosis Type 3 A... 展开 >> Sanfilippo Syndrome 收起 <<
Phase 1
Phase 2
Recruiting
December 2020
United States, Ohio
... 展开 >>
Nationwide Children's Hospital
Recruiting
Columbus, Ohio, United States, 43205
Contact: Krista Kunkler 614-722-2238 krista.kunkler@nationwidechildrens.org
Australia, South Australia
Women's and Children's Hospital
Recruiting
North Adelaide, South Australia, Australia, 5006
Contact: Louise Jaensch 08 8161 7295 louise.jaensch@sa.gov.au
Principal Investigator: Nicholas Smith, MD
Spain
Hospital Clínico Universitario de Santiago
Recruiting
Santiago De Compostela, Spain, 15706
Contact: Maria Luz Couce, MD +34 981 950 151 maria.luz.couce.pico@sergas.es
Contact: Maria Jose de Castro, MD +34 981 955 627 maria.jose.de.castro.lopez@sergas.es 收起 <<
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