STM2457
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货号：A1472918
STM2457 is an inhibitor of methyltransferase-like 3 (METTL3) and METTL14 complex with IC50 value of 16.9 µM.
STM2457 化学结构
STM2457 3D分子结构
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STM2457 纯度/质量文件 产品仅供科研
货号：A1472918
标准纯度：
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STM2457 质控信息
STM2457 生物活性
描述
STM2457 is an inhibitor of methyltransferase-like 3 (METTL3) and METTL14 complex with IC50 value of 16.9 µM [1] [2] [1]
STM2457 参考文献
[1] Yankova E, Blackaby W, Albertella M, Rak J, De Braekeleer E, Tsagkogeorga G, Pilka ES, Aspris D, Leggate D, Hendrick AG, Webster NA, Andrews B, Fosbeary R, Guest P, Irigoyen N, Eleftheriou M, Gozdecka M, Dias JML, Bannister AJ, Vick B, Jeremias I, Vassiliou GS, Rausch O, Tzelepis K, Kouzarides T. Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia. Nature. 2021 May;593(7860):597-601. doi: 10.1038/s41586-021-03536-w. Epub 2021 Apr 26. PMID: 33902106; PMCID: PMC7613134.
[2] Xu QC, Tien YC, Shi YH, Chen S, Zhu YQ, Huang XT, Huang CS, Zhao W, Yin XY. METTL3 promotes intrahepatic cholangiocarcinoma progression by regulating IFIT2 expression in an m6A-YTHDF2-dependent manner. Oncogene. 2022 Mar;41(11):1622-1633. doi: 10.1038/s41388-022-02185-1. Epub 2022 Jan 29. PMID: 35094011; PMCID: PMC8913368.
STM2457 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.25mL
0.45mL
0.23mL
11.25mL
2.25mL
1.12mL
22.50mL
4.50mL
2.25mL
STM2457 技术信息
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