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描述 | STM2457 is an inhibitor of methyltransferase-like 3 (METTL3) and METTL14 complex with IC50 value of 16.9 µM [1]. It inhibits the growth of a panel of acute myeloid leukemia (AML) cell lines (IC50 = 0.6-10.3 µM). STM2457 also inhibits the proliferation, migration and invasion of HuCC-T1 and HCCC-9810 intrahepatic cholangiocarcinoma cells (ICC) in a concentration-dependent manner [2]. When administered at a dose of 50 mg/kg, it increases survival in a patient-derived xenograft (PDX) mouse model of AML [1]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.25mL 0.45mL 0.23mL |
11.25mL 2.25mL 1.12mL |
22.50mL 4.50mL 2.25mL |
CAS号 | 2499663-01-1 |
分子式 | C25H28N6O2 |
分子量 | 444.53 |
SMILES Code | O=C(C(N=C1N2C=CC=C1)=CC2=O)NCC3=CN4C=C(CNCC5CCCCC5)C=CC4=N3 |
MDL No. | MFCD34368521 |
别名 | |
运输 | 蓝冰 |
InChI Key | OBERVORNENYOLE-UHFFFAOYSA-N |
Pubchem ID | 155167581 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Keep in dark place, sealed in dry, 2-8°C |
溶解方案 |
DMSO: 50 mg/mL(112.48 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |