产品说明书
STM2457
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同义名 : | - |
| CAS号 : | 2499663-01-1 | |
| 货号 : | A1472918 | |
| 分子式 : | C25H28N6O2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 444.529 | |
| MDL号 : | MFCD34368521 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(112.48 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | STM2457 is an inhibitor of methyltransferase-like 3 (METTL3) and METTL14 complex with IC50 value of 16.9 µM [1]. It inhibits the growth of a panel of acute myeloid leukemia (AML) cell lines (IC50 = 0.6-10.3 µM). STM2457 also inhibits the proliferation, migration and invasion of HuCC-T1 and HCCC-9810 intrahepatic cholangiocarcinoma cells (ICC) in a concentration-dependent manner [2]. When administered at a dose of 50 mg/kg, it increases survival in a patient-derived xenograft (PDX) mouse model of AML [1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.25mL 0.45mL 0.23mL |
11.25mL 2.25mL 1.12mL |
22.50mL 4.50mL 2.25mL |
| 参考文献 |
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