SIBA | 5'-Deoxy-5'-isobutylthioadenosine | Transmethylation Inhibitor

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SIBA {[allProObj[0].p_purity_real_show]}

货号：A654709 同义名： 5'-Deoxy-5'-isobutylthioadenosine;5'-Isobutylthioadenosine

SIBA selectively inhibits spermine synthase, IC50=8 μM.

SIBA 化学结构
CAS号：35899-54-8

SIBA 3D分子结构
CAS号：35899-54-8

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SIBA 纯度/质量文件产品仅供科研

货号：A654709 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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SIBA 生物活性

描述

Muscarinic receptors have been tentatively subclassified to M₁ and M₂ on the basis of differences in their affinity for the cholinergic antagonist pirenzepine. 5'-isobutylthio-adenosine (SIBA) is best known as inhibitor of S-adenosylhomocysteine hydrolase, but has also been implicated as inhihitors of protein synthesis, nucleic acid synthesis, viral replication, cellular differentiation, chemotaxis, polyamine metabolism and IgE-mediated histamine release. Most of these effects have been attributed to the inhibition of transmethylation reactions. SIBA also has biological and biochemical effects over muscarinic receptors other than on transmethylation reactions. SIBA, at 100 µM, inhibited [³H]N-methyl-scopolamine binding to homogenates of whole brain and cortex (mainly M1 subtype receptors) by 11-30% and to cerebellum (mainly M2 subtype receptors) by 20-39%. At 0.01-1.0 µM, stimulation of [³H]QNB and NMS-inaccessible [³H]QNB binding was observed, with the most induced by 1 µM 3-deaza-SIBA. In contrast, [³H]pirenzepine ([³H]PZ) binding to whole brain and cortex was inhibited in a dose-dependent manner with K_i values in the µM range^[3].

SIBA 参考文献

[1]Lawrence F, Bachrach U, et al. Effect of 5'-deoxy-5'-isobutylthioadenosine on putrescine uptake and polyamine biosynthesis by chick embryo fibroblasts. Biochem J. 1982 Jun 15;204(3):853-9.

[2]Carteni-Farina M, Della Ragione F, et al. Studies on the metabolism of 5'-isobutylthioadenosine (SIBA): phosphorolytic cleavage by methylthioadenosine phosphorylase. FEBS Lett. 1979 Aug 15;104(2):266-70.

[3]Muscarinic Receptor Subtype Specificity of 5'-(isobutylthio)-adenosine (SIBA) and Its Analogs

SIBA 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.95mL

0.59mL

0.29mL

14.73mL

2.95mL

1.47mL

29.46mL

5.89mL

2.95mL

SIBA 技术信息

CAS号	35899-54-8
分子式	C₁₄H₂₁N₅O₃S
分子量	339.413

别名	5'-Deoxy-5'-isobutylthioadenosine;5'-Isobutylthioadenosine
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C

溶解度

DMSO: 105 mg/mL(309.36 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

摩尔计算器

计算溶液所需的质量，体积或浓度。 Ambeed 摩尔浓度计算器基于以下方程式：

浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)=质量 (g)

浓度

体积

分子量

质量

SIBA {[allProObj[0].p_purity_real_show]}

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SIBA {[allProObj[0].p_purity_real_show]}

SIBA 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

SIBA 质控信息

SIBA 生物活性

SIBA 参考文献

SIBA 实验方案

SIBA 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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SIBA 纯度/质量文件产品仅供科研