SGN-2FF
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货号：A1364779
同义名：
2-fluorofucose
SGN-2FF 是一种口服生物利用度高的岩藻糖基转移酶 (fucosyltran sferas e ) 抑制剂。它有效地抑制岩藻糖基转移酶的活性，展现出显著的抗肿瘤 作用，特别是在癌症研究中具有潜在应用价值。
SGN-2FF 化学结构
SGN-2FF 3D分子结构
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SGN-2FF 纯度/质量文件 产品仅供科研
货号：A1364779
标准纯度：
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产品说明书
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SGN-2FF 质控信息
SGN-2FF 生物活性
描述
Fucosylation is the process of adding fucose sugar units to a molecule. It is a type of glycosylation. SGN-2FF is an orally bioavailable small-molecule inhibitor of glycoprotein fucosylation that has potential to enhance immune-mediated antitumor activity[1] [2]
SGN-2FF 参考文献
[1] Do, K.T., Chow, L.Q.M., Reckamp, K., Sanborn, R.E., Burris, H., Robert, F., Camidge, D.R., Steuer, C.E., Strickler, J.H., Weise, A., Specht, J.M., Gutierrez, M., Haughney, P., Hengel, S., Derleth, C.L. and Yap, T.A. (2021), First-In-Human, First-In-Class, Phase I Trial of the Fucosylation Inhibitor SGN-2FF in Patients with Advanced Solid Tumors. The Oncol, 26: 925-e1918.
[2] Nicole M. Okeley, Ryan A. Heiser, Weiping Zeng, Shawna Mae Hengel, Jason Wall, Peter C. Haughney, Timothy Anthony Yap, Francisco Robert, Rachel E. Sanborn, Howard Burris, Laura Q. Chow, Khanh T. Do, Martin Gutierrez, Karen Reckamp, Amy Weise, D Ross Camidge, John Strickler, Conor Steuer, Zejing Wang, Megan M. O'Meara, Stephen C. Alley, Shyra J. Gardai; Abstract 5551: SGN-2FF: A small-molecule inhibitor of fucosylation modulates immune cell activity in preclinical models and demonstrates pharmacodynamic activity in early phase 1 analysis. Cancer Res 1 July 2018; 78 (13_Supplement): 5551.
SGN-2FF 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
6.02mL
1.20mL
0.60mL
30.09mL
6.02mL
3.01mL
60.19mL
12.04mL
6.02mL
SGN-2FF 技术信息
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