产品说明书
SGN-2FF
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同义名 : | 2-fluorofucose |
| CAS号 : | 2089647-47-0 | |
| 货号 : | A1364779 | |
| 分子式 : | C6H11FO4 | |
| 纯度 : | 98% | |
| 分子量 : | 166.148 | |
| MDL号 : | N/A | |
| 存储条件： |
粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(300.94 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 35 mg/mL(210.66 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Fucosylation is the process of adding fucose sugar units to a molecule. It is a type of glycosylation. SGN-2FF is an orally bioavailable small-molecule inhibitor of glycoprotein fucosylation that has potential to enhance immune-mediated antitumor activity[1]. SGN-2FF treatment of nude mice, which maintain functional B cells and antibody production, resulted in a delay in LS174T tumor growth compared with untreated mice. The antitumor effect of SGN-2FF in syngeneic mouse model appeared to be dependent on T cell activity. Preclinical assays were applied in patient samples and results showed cell surface fucosylation on granulocytes was significantly reduced and neutrophil count was significantly increased in 6 of 7 treated subjects[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
6.02mL 1.20mL 0.60mL |
30.09mL 6.02mL 3.01mL |
60.19mL 12.04mL 6.02mL |
| 参考文献 |
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