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S-Gboxin {[allProObj[0].p_purity_real_show]}

货号：A1149112

S-Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma.

S-Gboxin 化学结构
CAS号：2101317-21-7

S-Gboxin 3D分子结构
CAS号：2101317-21-7

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S-Gboxin 纯度/质量文件产品仅供科研

货号：A1149112 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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S-Gboxin 生物活性

描述

Glioblastoma (GBM) is the most aggressive and prevalent primary malignancy of the central nervous system. S-Gboxin, a functional analog of gboxin, specifically inhibits primary mouse and human GBM cell growth with an IC₅₀ value of 470 nM. Antitumor activity was first assessed by daily S-Gboxin treatment at 10 mg/kg/day beginning on day 3 or day 14 after mouse GBM (HTS cells) allograft flank implantation. S-Gboxin treated mice showed reduced tumor volume, cellular density, proliferation, and enhanced survival in comparison to vehicle controls. S-Gboxin treated tumors had reduced expression of the high-grade glioma makers, GFAP and Olig2. Primary human GBM cells were also injected into flanks of immunocompromised mice in the presence of matrigel. After visible tumors were detected (3 days) S-Gboxin was administered daily (10 mg/kg/day) resulting in significant attenuation of growth and decreased cellular density compared to controls. Further, S-Gboxin treatment (2.16 μg/day/mouse) inhibited tumor growth as manifested by reduced hemorrhaging, cellular density, and decreased proliferation. Histopathology analysis further showed reduced expression of the high-grade glioma makers. Moreover, S-Gboxin demonstrated inhibition of GBM PDX growth as manifested by general health status, reduced cellular density, cellular proliferation, and GBM marker expression^[1].

S-Gboxin 参考文献

[1]Shi Y, Lim SK, Liang Q, et al. Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Nature. 2019;567(7748):341‐346

S-Gboxin 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.67mL

0.33mL

0.17mL

8.33mL

1.67mL

0.83mL

16.65mL

3.33mL

1.67mL

S-Gboxin 技术信息

CAS号	2101317-21-7
分子式	C₂₇H₃₂F₃IN₂O₂
分子量	600.455

别名
运输	蓝冰

存储条件

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 95 mg/mL(158.21 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 1 mg/mL(1.67 mM)，配合低频超声，并水浴加热至45℃助溶

动物实验配方

摩尔计算器

计算溶液所需的质量，体积或浓度。 Ambeed 摩尔浓度计算器基于以下方程式：

浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)=质量 (g)

浓度

体积

分子量

质量

S-Gboxin {[allProObj[0].p_purity_real_show]}

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S-Gboxin 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

S-Gboxin 质控信息

S-Gboxin 生物活性

S-Gboxin 参考文献

S-Gboxin 实验方案

S-Gboxin 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

细胞研究

临床研究

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