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Rosmarinic acid

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Chemical Structure| 20283-92-5 同义名 : Labiatenic acid;Rosemary acid;NPLC 0542;RM 21A;Labiatic acid
CAS号 : 20283-92-5
货号 : A796919
分子式 : C18H16O8
纯度 : 98%
分子量 : 360.315
MDL号 : MFCD00017740
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(166.52 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Rosmarinic acid is specific inhibitor of ε-Pol. The rosmarinic acid treatment significantly decreased extracellular HBV DNA with rough estimation of EC50 of 30 μM[3]. in vitro, rosmarinic acid significantly affected root morphology causing an inhibition of both total and primary root length with 71 μM and 175 μM ED50 values, respectively[4]. in vivo, rosmarinic acid at a dose of 50 mg/kg induced a decrease in the total cholesterol and triglyceride concentrations[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.78mL

0.56mL

0.28mL

13.88mL

2.78mL

1.39mL

27.75mL

5.55mL

2.78mL
参考文献

[1]Andrade JM, Dos Santos Passos C, et al. Combining in vitro and in silico approaches to evaluate the multifunctional profile of rosmarinic acid from Blechnum brasiliense on targets related to neurodegeneration. Chem Biol Interact. 2016 Jul 25;254:135-45.

[2]Fernando PM, Piao MJ, et al. Rosmarinic Acid Attenuates Cell Damage against UVB Radiation-Induced Oxidative Stress via Enhancing Antioxidant Effects in Human HaCaT Cells. Biomol Ther (Seoul). 2016 Jan;24(1):75-84.

[3]Tsukamoto Y, Ikeda S, Uwai K, et al. Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction. PLoS One. 2018;13(5):e0197664. Published 2018 May 21.

[4]Araniti F, Costas-Gil A, Cabeiras-Freijanes L, et al. Rosmarinic acid induces programmed cell death in Arabidopsis seedlings through reactive oxygen species and mitochondrial dysfunction. PLoS One. 2018;13(12):e0208802. Published 2018 Dec 26.

[5]Zych M, Kaczmarczyk-Sedlak I, Wojnar W, Folwarczna J. Effect of Rosmarinic Acid on the Serum Parameters of Glucose and Lipid Metabolism and Oxidative Stress in Estrogen-Deficient Rats. Nutrients. 2019;11(2):267. Published 2019 Jan 25.