Rosavin, a natural product isolated and purified from the herb of Rhodiola rosea L. with anti-fatigue effect, decreases neovascular reaction on cutaneous angiogenesis induced in mice after grafting of syngeneic tumor cells.
Rosavin is isolated from R. rosea, Rosavin shows antidepressant-like, adaptogenic, anxiolytic-like effects in mice model[2]. Furthermore, rosavin promoted osteogenesis in bone marrow mesenchymal stem cells (BMSCs). In vivo experiments showed that treatment with rosavin could alleviate ovariectomy-induced osteoporosis in mice. Rosavin suppressed RANKL (receptor activator of nuclear factor-κB)-induced osteoclastogenesis in vivo and in vitro by blocking the NF-κB and MAPK (mitogen-activated protein kinase) pathways[3]. Rosavin could significantly ameliorate the lung index and Pathological structure of mice with Pulmonary fibrosis by bleomycin-induced. Additionally, Rosavin could evidently decreased inflammatory cells infiltration in bronchoalveolar lavage fluid and pro-inflammatory cytokines expression in lung tissue specimens induced by bleomycin. Rosavin could down-regulate the expression of hydroxyproline and malondialdehyde and increased the activities of superoxide dismutase, glutathione peroxidase in lung tissue. The expression of Nrf2 were increased, and the expression of NF-κB p65, TGF-β1 and α-SMA were inhibited[4].
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