雷马曲班 /Ramatroban
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货号：A436709
同义名：
BAY u3405;Bay u3405
Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis.
Ramatroban 化学结构
Ramatroban 3D分子结构
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Ramatroban 纯度/质量文件 产品仅供科研
货号：A436709
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Ramatroban 质控信息
Ramatroban 生物活性
描述
Ramatroban is a selective thromboxane A2 (TxA2, IC50=14 nM) antagonist, which also antagonizes CRTH2 (IC50=113 nM) by inhibiting PGD2 binding. Ramatroban also inhibits human CYP isoform CYP2C9 with an IC50 of 15 μM[3] [4] [5] [6] [7]
Ramatroban 参考文献
[1] Ishizuka T, Matsui T, et al. Ramatroban (BAY u 3405): a novel dual antagonist of TXA2 receptor and CRTh2, a newly identified prostaglandin D2 receptor. Cardiovasc Drug Rev. 2004 Summer;22(2):71-90.
[2] Sundstrom E, Låstbom L, et al. Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung. J Pharmacol Exp Ther. 2003 Oct;307(1):408-18.
[3] Sugimoto H, Shichijo M, Iino T, Manabe Y, Watanabe A, Shimazaki M, Gantner F, Bacon KB. An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. J Pharmacol Exp Ther. 2003 Apr;305(1):347-52
[4] Gupta A, Kalantar-Zadeh K, Reddy ST. Ramatroban as a Novel Immunotherapy for COVID-19. J Mol Genet Med. 2020;14(3):10.37421
[5] Xue L, Gyles SL, Wettey FR, Gazi L, Townsend E, Hunter MG, Pettipher R. Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells. J Immunol. 2005 Nov 15;175(10):6531-6
[6] Pang J, Qi X, Luo Y, Li X, Shu T, Li B, Song M, Liu Y, Wei D, Chen J, Wang J, Wang C. Multi-omics study of silicosis reveals the potential therapeutic targets PGD2 and TXA2. Theranostics. 2021 Jan 1;11(5):2381-2394
[7] Uller L, Mathiesen JM, Alenmyr L, Korsgren M, Ulven T, Högberg T, Andersson G, Persson CG, Kostenis E. Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation. Respir Res. 2007 Feb 28;8(1):16
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Ramatroban 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.40mL
0.48mL
0.24mL
12.01mL
2.40mL
1.20mL
24.01mL
4.80mL
2.40mL
Ramatroban 技术信息
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