Proadifen (SKF-525A) HCl is a P450 monooxygenase inhibitor with potential anti-proliferative activity and the ability to potentiate the toxicity of hypericin-mediated photodynamic therapy and mitoxantrone via alteration of ABC transport proteins[2]. Adult male Wistar rats were administered SKF525 (proadifen hydrochloride) forty-eight, twenty-four, and one hour before electrophysiological assessments. It was found that the SKF525 inhibits the excitability of 5-HT neurons[3]. Proadifen inhibited the growth of HT-29 cells by the accumulation of cells in the G1 phase of the cell cycle, reduction of metabolic activity and colony formation and by the induction of apoptosis[4]. Moreover, proadifen (10 mM) also inhibited acetylcholine-induced hyperpolarization in the presence of L-NOARG plus indomethacin[5]. Proadifen may possess complex interactions with muscarinic receptors and Ca2+ entry blocking properties in concentrations 10-100 times lower than those reported to inhibit cytochrome P450-catalysed reactions[6].
搜索
