Proadifen HCl
产品说明书
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同义名 : | 盐酸丙基解痉素 ;SKF-525A;U-5446;NSC 170997;SKF 525A (hydrochloride);RP-5171;Proadifen hydrochloride |
| CAS号 : | 62-68-0 | |
| 货号 : | A263311 | |
| 分子式 : | C23H32ClNO2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 389.959 | |
| MDL号 : | MFCD00055151 | |
| 存储条件： |
Pure form Inert atmosphere,Store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(128.22 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Proadifen (SKF-525A) HCl is a P450 monooxygenase inhibitor with potential anti-proliferative activity and the ability to potentiate the toxicity of hypericin-mediated photodynamic therapy and mitoxantrone via alteration of ABC transport proteins[2]. Adult male Wistar rats were administered SKF525 (proadifen hydrochloride) forty-eight, twenty-four, and one hour before electrophysiological assessments. It was found that the SKF525 inhibits the excitability of 5-HT neurons[3]. Proadifen inhibited the growth of HT-29 cells by the accumulation of cells in the G1 phase of the cell cycle, reduction of metabolic activity and colony formation and by the induction of apoptosis[4]. Moreover, proadifen (10 mM) also inhibited acetylcholine-induced hyperpolarization in the presence of L-NOARG plus indomethacin[5]. Proadifen may possess complex interactions with muscarinic receptors and Ca2+ entry blocking properties in concentrations 10-100 times lower than those reported to inhibit cytochrome P450-catalysed reactions[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.56mL 0.51mL 0.26mL |
12.82mL 2.56mL 1.28mL |
25.64mL 5.13mL 2.56mL |
| 参考文献 |
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