TAS-116 is a potent and selective HSP90α/β inhibitor with Kis of 34.7 nM, 21.3 nM, respectively.
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描述 | TAS-116 is a potent and selective HSP90α/β inhibitor with Kis of 34.7 nM, 21.3 nM, respectively. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT02965885 | Advanced Solid Tumors | Phase 1 | Recruiting | March 2020 | United States, Ohio ... 展开 >> Gabrail Cancer Center Recruiting Canton, Ohio, United States, 44718 University Hospitals Case Medical Center Recruiting Cleveland, Ohio, United States, 44106 United States, South Carolina Greenville Health System, Institute for Translational Oncology Research Recruiting Greenville, South Carolina, United States, 29605 United States, Virginia US Oncology - Virginia Cancer Specialists, P.C. Recruiting Fairfax, Virginia, United States, 86885 Italy Policlinico S.Orsola-Malpighi, U.O. Oncologia Medica Recruiting Bologna, Italy, 40138 Contact: Stefania Salvagni 0039 0512142204 stefania.salvagni@aosp.bo.it Azienda Ospedaliero-Universitaria Policlinico-Vittorio Emanuele Oncologia Medica Recruiting Catania, Italy, 95123 Contact: Soto Parra 0039 0953782426 hsotoparra@policlinico.unict.it Contact hsotoparra@yahoo.it Istituto Europeo di Oncologia , Sviluppo di Nuovi Farmaci per Terapie Innovative Recruiting Milano, Italy, 20141 Contact: Giuseppe Curigliano 0039 0257489439 giuseppe.curigliano@ieo.it Regina Elena National Cancer Institute Not yet recruiting Roma, Italy, 00144 Contact: Francesco Cognetti 0039 0652666919 francesco.cognetti@ifo.gov.it United Kingdom Northern Centre for Cancer Care Recruiting Newcastle Upon Tyne, England, United Kingdom Contact: Ruth Plummer +44 (0) 191 208 4414 Ruth.Plummer@newcastle.ac.uk Division of Cancer Studies, Kings College London Recruiting London, United Kingdom, SE19 9RT Sarah Cannon Research Institute UK Recruiting London, United Kingdom, W1G 6AD The Christie NHS Foundation Trust Institute of Cancer Sciences, University of Manchester Recruiting Manchester, United Kingdom, M20 4BX Royal Marsden Recruiting Sutton, United Kingdom, SM2 5PTT 收起 << |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.20mL 0.44mL 0.22mL |
11.00mL 2.20mL 1.10mL |
22.00mL 4.40mL 2.20mL |
CAS号 | 1260533-36-5 |
分子式 | C25H26N8O |
分子量 | 454.527 |
别名 | Tas-116 |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Sealed in dry,Store in freezer, under -20°C |
溶解度 |
DMSO: 120 mg/mL(264.01 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |