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Pimitespib

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Chemical Structure| 1260533-36-5 同义名 : Tas-116
CAS号 : 1260533-36-5
货号 : A423911
分子式 : C25H26N8O
纯度 : 99%+
分子量 : 454.527
MDL号 : MFCD28502196
存储条件:

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 120 mg/mL(264.01 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 TAS-116 is a potent and selective HSP90α/β inhibitor with Kis of 34.7 nM, 21.3 nM, respectively.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02965885 Advanced Solid Tumors Phase 1 Recruiting March 2020 United States, Ohio ... 展开 >> Gabrail Cancer Center Recruiting Canton, Ohio, United States, 44718 University Hospitals Case Medical Center Recruiting Cleveland, Ohio, United States, 44106 United States, South Carolina Greenville Health System, Institute for Translational Oncology Research Recruiting Greenville, South Carolina, United States, 29605 United States, Virginia US Oncology - Virginia Cancer Specialists, P.C. Recruiting Fairfax, Virginia, United States, 86885 Italy Policlinico S.Orsola-Malpighi, U.O. Oncologia Medica Recruiting Bologna, Italy, 40138 Contact: Stefania Salvagni    0039 0512142204    stefania.salvagni@aosp.bo.it    Azienda Ospedaliero-Universitaria Policlinico-Vittorio Emanuele Oncologia Medica Recruiting Catania, Italy, 95123 Contact: Soto Parra    0039 0953782426    hsotoparra@policlinico.unict.it    Contact       hsotoparra@yahoo.it    Istituto Europeo di Oncologia , Sviluppo di Nuovi Farmaci per Terapie Innovative Recruiting Milano, Italy, 20141 Contact: Giuseppe Curigliano    0039 0257489439    giuseppe.curigliano@ieo.it    Regina Elena National Cancer Institute Not yet recruiting Roma, Italy, 00144 Contact: Francesco Cognetti    0039 0652666919    francesco.cognetti@ifo.gov.it    United Kingdom Northern Centre for Cancer Care Recruiting Newcastle Upon Tyne, England, United Kingdom Contact: Ruth Plummer    +44 (0) 191 208 4414    Ruth.Plummer@newcastle.ac.uk    Division of Cancer Studies, Kings College London Recruiting London, United Kingdom, SE19 9RT Sarah Cannon Research Institute UK Recruiting London, United Kingdom, W1G 6AD The Christie NHS Foundation Trust Institute of Cancer Sciences, University of Manchester Recruiting Manchester, United Kingdom, M20 4BX Royal Marsden Recruiting Sutton, United Kingdom, SM2 5PTT 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.20mL

0.44mL

0.22mL

11.00mL

2.20mL

1.10mL

22.00mL

4.40mL

2.20mL