Phenazopyridine hydrochloride is a chemical, which has a local analgesic effect, often used to alleviate the pain, irritation, discomfort, or urgency caused by urinary tract infections, surgery, or injury to the urinary tract. Preoperative oral phenazopyridine is effective in more than 90% of cases to detect during gynecologic surgery. A higher phenazopyridine dose and lower intraoperative urine output were associated with increased efficacy[3]. Phenazopyridine hydrochloride was carcinogenic in Fischer 344 rats, inducing adenocarcinomas of the colon in both males and females. Although phenazopyridine hydrochloride was not carcinogenic in male B6C3F1 mice, the chemical was carcinogenic in females, inducing hepatocellular adenomas and carcinomas[4]. Dose-inhibition curves showed that three of these kinases interacted with phenazopyridine with sub-micromolar binding affinities: cyclin-G-associated kinase, and the two phosphatidylinositol kinases PI4KB and PIP4K2C, the latter being known for participating in pain induction. Docking revealed that phenazopyridine forms strong H-bonds with the hinge region of the ATP-binding pocket of these kinases. Phenazopyridine is a kinase inhibitor, impacting notably phosphatidylinositol kinases involved in nociception[5]. Phenazopyridine: (i) enhanced neuronal differentiation, (ii) increased cell survival, (iii) decreased the amount of non-neuronal and undifferentiated cells and (iv) synchronized the cellular differentiation state[6].
United States, Texas
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Research Imaging Institute, The University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229 收起 <<
United States, Texas
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Research Imaging Institute, The University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229 收起 <<
United States, Ohio
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University Hospitals Cleveland Medical Center
Recruiting
Cleveland, Ohio, United States, 44106
Contact: David Sheyn, MD 216-844-3896 david.sheyn@uhhospitals.org 收起 <<
Brazil
... 展开 >> Centro de Medicina Reprodutiva Carlos Isaia Filho Ltda
Not yet recruiting
Porto Alegre, Rio Grande do Sul, Brazil
Contact: Carlos Isaia Filho, MD
UNISA
Not yet recruiting
Santo Amaro, São Paulo, Brazil
Contact: Lucia Hime, MD
Marcio Antonio Pereira Clinica de Endocrinologia
Not yet recruiting
São José dos Campos, São Paulo, Brazil
Contact: Marcio A. Pereira, MD
AFIP
Not yet recruiting
São Paulo, Brazil
Contact: Helena H. Campos, MD
Savmed Clinica Médica S/C Ltda.
Not yet recruiting
São Paulo, Brazil
Contact: Felício Savióli, MD
Sociedade de atendimento Cardiológico LTDA
Not yet recruiting
São Paulo, Brazil
Contact: Nabil Ghorayeb, MD
Principal Investigator: Patrícia Smith, MD
USP
Not yet recruiting
São Paulo, Brazil
Contact: Ceci M Carvalho Lopes, MD 收起 <<
United States, Rhode Island
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Women & Infants Hospital of Rhode Island
Recruiting
Providence, Rhode Island, United States, 02903
Contact: Lauren E Stewart, MD 401-453-7560 ext 48762 lstewart@wihri.org 收起 <<
United States, Massachusetts
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University of Massachusetts
Recruiting
Worcester, Massachusetts, United States, 01605
Contact: Tania Sierra, MD 508-334-9840 tania.sierra@umassmemorial.org
Principal Investigator: Michael Flynn, MD 收起 <<
United States, New York
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Icahn School of Medicine at Mount Sinai
Recruiting
New York, New York, United States, 10029
Contact: Joyce Preisinger 212-241-7090 joyce.preisinger@mssm.edu
Principal Investigator: Charles Ascher-Walsh, M.D.
Sub-Investigator: Annacecilia Peacher-Seaney, M.D. 收起 <<
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