产品说明书
Phenazopyridine hydrochloride
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同义名 : | Phenazopyridine HCl;Phenazopyridine (hydrochloride) |
| CAS号 : | 136-40-3 | |
| 货号 : | A416289 | |
| 分子式 : | C11H12ClN5 | |
| 纯度 : | 98% | |
| 分子量 : | 249.7 | |
| MDL号 : | MFCD00035347 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 25 mg/mL(100.12 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 1 mg/mL(4 mM)，配合低频超声，并水浴加热至45℃助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Phenazopyridine hydrochloride is a chemical, which has a local analgesic effect, often used to alleviate the pain, irritation, discomfort, or urgency caused by urinary tract infections, surgery, or injury to the urinary tract. Preoperative oral phenazopyridine is effective in more than 90% of cases to detect during gynecologic surgery. A higher phenazopyridine dose and lower intraoperative urine output were associated with increased efficacy[3]. Phenazopyridine hydrochloride was carcinogenic in Fischer 344 rats, inducing adenocarcinomas of the colon in both males and females. Although phenazopyridine hydrochloride was not carcinogenic in male B6C3F1 mice, the chemical was carcinogenic in females, inducing hepatocellular adenomas and carcinomas[4]. Dose-inhibition curves showed that three of these kinases interacted with phenazopyridine with sub-micromolar binding affinities: cyclin-G-associated kinase, and the two phosphatidylinositol kinases PI4KB and PIP4K2C, the latter being known for participating in pain induction. Docking revealed that phenazopyridine forms strong H-bonds with the hinge region of the ATP-binding pocket of these kinases. Phenazopyridine is a kinase inhibitor, impacting notably phosphatidylinositol kinases involved in nociception[5]. Phenazopyridine: (i) enhanced neuronal differentiation, (ii) increased cell survival, (iii) decreased the amount of non-neuronal and undifferentiated cells and (iv) synchronized the cellular differentiation state[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02476448 | Injury of Ureter | Not Applicable | Completed | - | United States, Florida ... 展开 >> Cleveland Clinic Florida Weston, Florida, United States, 33331 收起 << |
| NCT00305071 | Pyuria Urinar... 展开 >>y Tract Infections 收起 << | Phase 2 | Unknown | - | Taiwan ... 展开 >> Min-Sheng General Hospital Not yet recruiting Taoyuan City, Taiwan, 320 Contact: Po-Chien Huang, MD 886-3-3179599 ext 8223 m001435@e-ms.com.tw 收起 << |
| NCT02380573 | Mild Cognitive Impairment ... 展开 >> MCI Aging Alzheimer's Disease AD 收起 << | Phase 2 | Active, not recruiting | July 2019 | United States, Texas ... 展开 >> Research Imaging Institute, The University of Texas Health Science Center at San Antonio San Antonio, Texas, United States, 78229 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.00mL 0.80mL 0.40mL |
20.02mL 4.00mL 2.00mL |
40.05mL 8.01mL 4.00mL |
| 参考文献 |
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