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Palovarotene

货号:A547752 同义名: R 667;Ro 3300074

Palovarotene是选择性的视黄酸受体 γ (RAR-γ) 激动剂,用于治疗肺气肿。

Palovarotene 化学结构 CAS号:410528-02-8
Palovarotene 化学结构
CAS号:410528-02-8
Palovarotene 3D分子结构
CAS号:410528-02-8
Palovarotene 化学结构 CAS号:410528-02-8
Palovarotene 3D分子结构 CAS号:410528-02-8
规格 价格 库存 数量
50μL*10mM(DMSO) ¥129 咨询
100μL*10mM(DMSO) ¥298 咨询
250μL*10mM(DMSO) ¥570 咨询
500μL*10mM(DMSO) ¥818 咨询
10mM*1mL(DMSO) ¥1078 咨询
1mg ¥401 咨询
5mg ¥502 咨询
10mg ¥1002 咨询
25mg ¥1497 咨询
50mg ¥2993 咨询
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Palovarotene 纯度/质量文件 产品仅供科研

货号:A547752 标准纯度:
批次查询: 批次纯度:

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Palovarotene 生物活性

描述 Palovarotene is a selective retinoic acid receptor gamma (RAR-γ) agonist for the treatment of emphysema.
体内研究

Palovarotene effectively inhibits post-traumatic chondrogenesis and osteogenesis, along with mitigating trauma-induced ectopic bone formation. Administered orally at 1 mg/kg/day for 14 days, starting either on post-operative day (POD) 1 or POD-5, palovarotene significantly inhibits subcutaneous and intramuscular heterotopic ossification (HO) in mice. Assessment for up to 84 days post-injury demonstrates a 50 to 60% reduction in HO regardless of treatment initiation time or the presence of infection, compared to vehicle-control animals [1].

In Acvr1cR206H/+ mice, palovarotene treatment for 14 days via daily gavage starting from day 1 of injury significantly diminishes HO formation by over 80% based on bone volume/total volume quantification, compared to mice receiving vehicle as control [2].

Palovarotene 参考文献

[1]Pavey GJ, et al. Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model. Bone. 2016 Sep;90:159-67.

[2]Xiao WH, et al. Olesoxime (cholest-4-en-3-one, oxime): analgesic and neuroprotective effects in a rat model of painful peripheral neuropathy produced by the chemotherapeutic agent, paclitaxel. Pain. 2009 Dec 15;147(1-3):202-9

Palovarotene 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.41mL

0.48mL

0.24mL

12.06mL

2.41mL

1.21mL

24.12mL

4.82mL

2.41mL

Palovarotene 技术信息

CAS号410528-02-8
分子式C27H30N2O2
分子量 414.539
别名 R 667;Ro 3300074
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C

溶解度

DMSO: 25 mg/mL(60.31 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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