Palovarotene

产品说明书

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Chemical Structure| 410528-02-8 同义名 : R 667;Ro 3300074
CAS号 : 410528-02-8
货号 : A547752
分子式 : C27H30N2O2
纯度 : 99%
分子量 : 414.539
MDL号 : MFCD10565968
存储条件:

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 25 mg/mL(60.31 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Palovarotene is a selective retinoic acid receptor gamma (RAR-γ) agonist for the treatment of emphysema.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.41mL

0.48mL

0.24mL

12.06mL

2.41mL

1.21mL

24.12mL

4.82mL

2.41mL

参考文献

[1]Pavey GJ, et al. Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model. Bone. 2016 Sep;90:159-67.

[2]Xiao WH, et al. Olesoxime (cholest-4-en-3-one, oxime): analgesic and neuroprotective effects in a rat model of painful peripheral neuropathy produced by the chemotherapeutic agent, paclitaxel. Pain. 2009 Dec 15;147(1-3):202-9