产品说明书

Oxytocin

Print
Chemical Structure| 50-56-6 同义名 : α-Hypophamine;Oxytocic hormone;Syntocinon
CAS号 : 50-56-6
货号 : A387421
分子式 : C43H66N12O12S2
纯度 : 98% (contains 6-10%HOAc)
分子量 : 1007.187
MDL号 : MFCD00076731
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(104.25 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 The OXTR (oxytocin receptor), a 7-transmembrane G protein-coupled receptor capable of binding to either Gαi or Gαq proteins, activates a set of signaling cascades, such as the MAPK, PKC, PLC, or CaMK pathways, which converge on transcription factors like CREB or MEF-2[3]. Oxytocin has been regulating reproductive and social behaviors for more than 500 million years. In all mammals, oxytocin is the hormone indispensable for milk-ejection during nursing (maternal milk provision to offspring), a process that is crucial for successful mammalian parental care. In laboratory mice, a remarkable transcriptional activation occurs during parental behavior within the anterior commissural nucleus (AC), the largest magnocellular oxytocin cell population within the medial preoptic area[4]. Oxytocin has also been linked to many domains within the realm of "social cognition." For example, oxytocin affects trusting behavior, cooperation, as well as the perception and processing of facial expressions. Furthermore, oxytocin increases empathy and seems to exert differential effects on in-group versus out-group preferences[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03742531 Oxytocin Indu... 展开 >>ction of Labor 收起 << Phase 2 Recruiting January 1, 2019 Turkey ... 展开 >> Zeynep Kamil Education and Research Hospital Recruiting Istanbul, Turkey Contact: ahmet eser    905067136880    hicoice@yahoo.com 收起 <<
NCT02647268 Postpartum Hemorrhage Not Applicable Completed - Canada, Ontario ... 展开 >> Mount Sinai Hospital Toronto, Ontario, Canada, M5G1X5 收起 <<
NCT03640156 Autism Spectrum Disorder Phase 3 Recruiting December 2019 Belgium ... 展开 >> Katholieke Universiteit Leuven Recruiting Leuven, Belgium, 3000 Principal Investigator: Kaat Alaerts, PhD 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.99mL

0.20mL

0.10mL

4.96mL

0.99mL

0.50mL

9.93mL

1.99mL

0.99mL
参考文献

[1]Gao S, Becker B, et al. Oxytocin, the peptide that bonds the sexes also divides them. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7650-4.

[2]Granat M. Oxytocin contraindicated in presence of uterine scar. Lancet. 1976 Dec 25;2(8000):1411.

[3]The Oxytocin Receptor: From Intracellular Signaling to Behavior

[4]Oxytocin and Parental Behaviors

[5]Oxytocin and Social Cognition