货号:A155966 同义名: 奥比他韦(ABT-267) / ABT-267
Ombitasvir is inhibitor of hepatitis C virus protein NS5A with EC50s of 0.82 pM to 19.3 pM against HCV genotypes 1 to 5.
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描述 | Hepatitis C virus (HCV) is an enveloped, single-stranded, positive-sense RNA virus in the Flaviviridae family. Ombitasvir is a HCV NS5A inhibitor with pan-genotypic activity. Ombitasvir had EC50s of 14.1 and 5.0 pM against genotype 1a-H77 and 1b-Con1 sub-genomic replicons, respectively. It demonstrated broad genotypic activity, with EC50s of 0.82 to 19.3 pM against genotype 2a, 2b, 3a, 4a, and 5a replicons and 366 pM against a genotype 6a replicon. Among a panel of HCV genotype 1 to 6 isolates, the EC50 of ombitasvir ranged from 0.1 to15.1 pM against NS5A from 66 genotype 1 to 5 isolates. In addition, ombitasvir was active against the genotype 2a JFH-1 replicon, with an EC50 of 0.82 pM. In a 3-day monotherapy study (5, 25, 50, or 200 mg; once daily) in 12 HCV genotype 1-infected patients, decreases in HCV RNA up to 3.1 log10 IU/ml were observed. And wild-type virus was largely suppressed by ombitasvir during 3-day monotherapy, and at doses higher than 5 mg, resistant variant M28V was also suppressed[3]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.12mL 0.22mL 0.11mL |
5.59mL 1.12mL 0.56mL |
11.18mL 2.24mL 1.12mL |
CAS号 | 1258226-87-7 |
分子式 | C50H67N7O8 |
分子量 | 894.109 |
别名 | 奥比他韦(ABT-267) ;ABT-267 |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 35 mg/mL(39.15 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |