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首页 / 抑制剂/激动剂 / 抗感染 / 丙型肝炎病毒 / Ombitasvir

奥比他韦 /Ombitasvir {[allProObj[0].p_purity_real_show]}

货号：A155966 同义名： 奥比他韦（ABT-267） / ABT-267 Ambeed 开学季，买赠积分，赢豪礼

Ombitasvir is inhibitor of hepatitis C virus protein NS5A with EC50s of 0.82 pM to 19.3 pM against HCV genotypes 1 to 5.

Ombitasvir 化学结构 CAS号：1258226-87-7
Ombitasvir 化学结构
CAS号：1258226-87-7
Ombitasvir 3D分子结构
CAS号：1258226-87-7
Ombitasvir 化学结构 CAS号：1258226-87-7
Ombitasvir 3D分子结构 CAS号：1258226-87-7
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Ombitasvir 纯度/质量文件 产品仅供科研

货号：A155966 标准纯度： {[allProObj[0].p_purity_real_show]}
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Ombitasvir 生物活性

描述 Hepatitis C virus (HCV) is an enveloped, single-stranded, positive-sense RNA virus in the Flaviviridae family. Ombitasvir is a HCV NS5A inhibitor with pan-genotypic activity. Ombitasvir had EC50s of 14.1 and 5.0 pM against genotype 1a-H77 and 1b-Con1 sub-genomic replicons, respectively. It demonstrated broad genotypic activity, with EC50s of 0.82 to 19.3 pM against genotype 2a, 2b, 3a, 4a, and 5a replicons and 366 pM against a genotype 6a replicon. Among a panel of HCV genotype 1 to 6 isolates, the EC50 of ombitasvir ranged from 0.1 to15.1 pM against NS5A from 66 genotype 1 to 5 isolates. In addition, ombitasvir was active against the genotype 2a JFH-1 replicon, with an EC50 of 0.82 pM. In a 3-day monotherapy study (5, 25, 50, or 200 mg; once daily) in 12 HCV genotype 1-infected patients, decreases in HCV RNA up to 3.1 log10 IU/ml were observed. And wild-type virus was largely suppressed by ombitasvir during 3-day monotherapy, and at doses higher than 5 mg, resistant variant M28V was also suppressed[3].

Ombitasvir 参考文献

[1]Krishnan P, Beyer J, et al. In vitro and in vivo antiviral activity and resistance profile of ombitasvir, an inhibitor of hepatitis C virus NS5A. Antimicrob Agents Chemother. 2015 Feb;59(2):979-87.

[2]DeGoey DA, Randolph JT, et al. Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A. J Med Chem. 2014 Mar 13;57(5):2047-57.

[3]Krishnan P, Beyer J, Mistry N, Koev G, Reisch T, DeGoey D, Kati W, Campbell A, Williams L, Xie W, Setze C, Molla A, Collins C, Pilot-Matias T. In vitro and in vivo antiviral activity and resistance profile of ombitasvir, an inhibitor of hepatitis C virus NS5A. Antimicrob Agents Chemother. 2015 Feb;59(2):979-87

Ombitasvir 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.12mL

0.22mL

0.11mL

5.59mL

1.12mL

0.56mL

11.18mL

2.24mL

1.12mL

Ombitasvir 技术信息

CAS号1258226-87-7
分子式C50H67N7O8
分子量 894.109
别名 奥比他韦（ABT-267） ;ABT-267
运输蓝冰
存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 35 mg/mL(39.15 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Ombitasvir | ABT-267 | 奥比他韦（ABT-267） | HCV | AmBeed-信号通路专用抑制剂 | Ombitasvir 纯度/质量文件 | Ombitasvir 生物活性 | Ombitasvir 参考文献 | Ombitasvir 实验方案 | Ombitasvir 技术信息

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