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首页 / 抑制剂/激动剂 / G蛋白偶联受体/G蛋白 / 血管紧张素受体 / Olmesartan medoxomil

奥美沙坦酯 /Olmesartan medoxomil {[allProObj[0].p_purity_real_show]}

货号：A131632 同义名： CS 866

Olmesartan Medoxomil is a synthetic imidazole-derived angiotensin II receptor antagonist, acting as a prodrug with an antihypertensive property.

Olmesartan medoxomil 化学结构 CAS号：144689-63-4
Olmesartan medoxomil 化学结构
CAS号：144689-63-4
Olmesartan medoxomil 3D分子结构
CAS号：144689-63-4
Olmesartan medoxomil 化学结构 CAS号：144689-63-4
Olmesartan medoxomil 3D分子结构 CAS号：144689-63-4
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Olmesartan medoxomil 纯度/质量文件 产品仅供科研

货号：A131632 标准纯度： {[allProObj[0].p_purity_real_show]}
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Olmesartan medoxomil 生物活性

描述 Inhibition of Arachidonic acid (AA) metabolism by angiotensin II receptor blockers (ARBs) occurs in a concentration-dependent manner, with Olmesartan showing an IC50 of 66.2 μM[1]. Olmesartan medoxomil is identified as a potent, selective blocker of the angiotensin AT1 receptor[2].
体内研究

The effectiveness of Olmesartan was evaluated in db/db diabetic mice over a 12-week period, starting from weeks 10 to 22 of age. These mice exhibited a significant increase in albuminuria (11.7-fold) compared to controls. Treatment with Olmesartan for twelve weeks notably reduced albuminuria by 77% versus placebo, and the albumin/creatinine ratio (ACR) saw a significant decrease by 59% in treated db/db mice, highlighting its potential benefits in diabetic conditions[3].
体外研究

Inhibition of Arachidonic acid (AA) metabolism by angiotensin II receptor blockers (ARBs) occurs in a concentration-dependent manner, with Olmesartan showing an IC50 of 66.2 μM[1].

Olmesartan medoxomil is identified as a potent, selective blocker of the angiotensin AT1 receptor[2].

Olmesartan medoxomil 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01271374 Hypertension Phase 4 Unknown December 2011 United States, Georgia ... 展开 >> Atlanta Clinical Research Center Tucker, Georgia, United States, 30084 收起 <<
NCT01870739 - Completed - -
NCT02089399 Healthy Phase 1 Completed - Korea, Republic of ... 展开 >> Samsung medical center Seoul, Korea, Republic of 收起 <<

Olmesartan medoxomil 参考文献

[1]Senda A, et al. Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8. Biol Pharm Bull. 2015;38(12):1975-9.

[2]Shah S, et al. Simultaneous Quantitative Analysis of Olmesartan Medoxomil and Amlodipine Besylate in Plasma by High-performance Liquid Chromatography Technique. J Young Pharm. 2012 Apr;4(2):88-94.

[3]Gu J, et al. Olmesartan Prevents Microalbuminuria in db/db Diabetic Mice Through Inhibition of Angiotensin II/p38/SIRT1-Induced Podocyte Apoptosis. Kidney Blood Press Res. 2016 Nov 21;41(6):848-864.

Olmesartan medoxomil 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.79mL

0.36mL

0.18mL

8.95mL

1.79mL

0.90mL

17.90mL

3.58mL

1.79mL

Olmesartan medoxomil 技术信息

CAS号144689-63-4
分子式C29H30N6O6
分子量 558.585
别名 CS 866
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C
溶解度

DMSO: 50 mg/mL(89.51 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Olmesartan medoxomil | 144689-63-4 | CS 866 | CS866 | CS-866 | Angiotensin Receptor Inhibitor | GPCR/G Protein | Angiotensin Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Olmesartan medoxomil 纯度/质量文件 | Olmesartan medoxomil 生物活性 | Olmesartan medoxomil 临床数据 | Olmesartan medoxomil 参考文献 | Olmesartan medoxomil 实验方案 | Olmesartan medoxomil 技术信息

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