产品说明书
Olmesartan medoxomil
 |
同义名 : | CS 866 |
| CAS号 : | 144689-63-4 | |
| 货号 : | A131632 | |
| 分子式 : | C29H30N6O6 | |
| 纯度 : | 98% | |
| 分子量 : | 558.585 | |
| MDL号 : | MFCD00944911 | |
| 存储条件： |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(89.51 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Inhibition of Arachidonic acid (AA) metabolism by angiotensin II receptor blockers (ARBs) occurs in a concentration-dependent manner, with Olmesartan showing an IC50 of 66.2 μM[1]. Olmesartan medoxomil is identified as a potent, selective blocker of the angiotensin AT1 receptor[2]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01271374 | Hypertension | Phase 4 | Unknown | December 2011 | United States, Georgia ... 展开 >> Atlanta Clinical Research Center Tucker, Georgia, United States, 30084 收起 << |
| NCT01870739 | - | Completed | - | - | |
| NCT02089399 | Healthy | Phase 1 | Completed | - | Korea, Republic of ... 展开 >> Samsung medical center Seoul, Korea, Republic of 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.79mL 0.36mL 0.18mL |
8.95mL 1.79mL 0.90mL |
17.90mL 3.58mL 1.79mL |
| 参考文献 |
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