Octanoic acid is found naturally in the milk of various mammals, and as a minor constituent of coconut oil and palm kernel oil. It is used in the production of esters used in perfumery and also in the manufacture of dyes.
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Type
HazMat fee for 500 gram (Estimated)
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Accessible (Haz class 3, 4, 5 or 8), International
Octanoic acid, also known as Caprylic acid, is an oily substance characterized by a slightly unpleasant, rancid taste. It finds widespread commercial use in creating esters for perfumery and in dye manufacturing. Additionally, Octanoic acid serves as a tremor-suppressing agent[1].[2].
体内研究
Administered intraperitoneally at 1500 mg/kg, Octanoic acid has been observed to suppress harmaline-induced tremors in a mouse model of essential tremor, showcasing its therapeutic potential in tremor control[1].
Given orally at 150 mg/kg, Octanoic acid demonstrates protective effects in a mouse model of Parkinson's Disease (PD) induced by MPTP, suggesting its neuroprotective capabilities[2].
At a dosage of 1.3 mg via oral administration, Octanoic acid enhances the catabolism of branched-chain amino acids (BCAAs) in rats by activating the branched-chain α-keto acid dehydrogenase complex (BCKDC) through the reduction of the bound form of branched-chain α-keto acid dehydrogenase kinase (BDK)[3].
体外研究
In experimental settings, Octanoic acid has shown to enhance glucose-stimulated insulin secretion (GSIS) in MIN6 cells at concentrations ranging from 0 to 0.5 mM over a half-hour period, doing so through the Olfr15 receptor via the PLC-IP3 signaling pathway[4].
At doses from 0 to 10 mM over 48 hours, Octanoic acid stimulates neurite outgrowth in PC12 cells and activates the p38 MAPK and ERK signaling pathways, indicating its potential neurotrophic effects[5].
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