Benzobicyclon是一种 4-HPPD 抑制剂，用作除草剂，能够通过形成活性除草剂苯并双环素水解物，导致杂草的白化和死亡。Benzobicyclon 对禾本科、莎草科和阔叶杂草有效，适用于抗磺酰脲除草剂抗性生物型和野生型杂草的防治研究。

Nitisinone is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase.

Mesotrione is a herbicide belongs to the benzoylcyclohexanedione family. Mesotrione is a potent and competitive and reversible inhibitor of HPPD enzyme. Mesotrione is selective to maize due to rapid metabolism and relative high tolerance by the susceptible crop plant.

Sulcotrione, a β-triketone herbicide, can inhibit hydroxyphenylpyruvate dioxygenase (HPPD).