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甲硫酸新斯的明 /Neostigmine methyl sulfate {[allProObj[0].p_purity_real_show]}

货号:A129666 同义名: 甲基硫酸新斯的明 / Neostigmine (methyl sulfate);Hodostin

Neostigmine methyl sulfate是一种胆碱酯酶抑制剂,用于治疗重症肌无力并逆转肌肉松弛药的作用,但无法通过血脑屏障。

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Neostigmine methyl sulfate 化学结构 CAS号:51-60-5
Neostigmine methyl sulfate 化学结构
CAS号:51-60-5
Neostigmine methyl sulfate 3D分子结构
CAS号:51-60-5
Neostigmine methyl sulfate 化学结构 CAS号:51-60-5
Neostigmine methyl sulfate 3D分子结构 CAS号:51-60-5
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Neostigmine methyl sulfate 纯度/质量文件 产品仅供科研

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Neostigmine methyl sulfate 生物活性

描述 Neostigmine Methyl Sulfate is acetylcholine esterase inhibitors as neuraxial adjuvant drug. The ED50 and ED95 of epidural neostigmine in combination with PCEA (patient controlled epidural analgesia ) for satisfactory analgesia after partial hepatectomy were 228.63 μg (95% CI = 197.95–299.77 μg) and 300.12 μg (95% CI = 259.44–741.65 μg)[2]. Moreover, the immediate and dramatic reversal of envenomation symptoms following the administration of the anticholinesterase neostigmine methyl sulfate[3]. The N-monophenylcarbamate analogues of neostigmine methyl sulfate have extended duration of cholinesterase inhibition as long-acting agents for myasthenia gravis[4].

Neostigmine methyl sulfate 参考文献

[1]Huang TH, Pan DH, et al. [Applications of A C oscillopolarographic titration in pharmaceutical analysis. I. Titration of neostigmine methyl sulfate injection with sodium tetraphenylborate] . Yao Xue Xue Bao. 1982 Jul;17(7):534-9.

[2]Zhong QS, Ge SJ, Wang B, Xue ZG. Optimal single-dose epidural neostigmine for postoperative analgesia after partial hepatectomy. Indian J Pharmacol. 2014 Nov-Dec;46(6):613-6.

[3]Gold BS. Neostigmine for the treatment of neurotoxicity following envenomation by the Asiatic cobra. Ann Emerg Med. 1996 Jul;28(1):87-9.

[4]Yu QS, Holloway HW, Luo W, Lahiri DK, Brossi A, Greig NH. Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine. Bioorg Med Chem. 2010 Jul 1;18(13):4687-93.

Neostigmine methyl sulfate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.99mL

0.60mL

0.30mL

14.95mL

2.99mL

1.50mL

29.91mL

5.98mL

2.99mL

Neostigmine methyl sulfate 技术信息

CAS号51-60-5
分子式C13H22N2O6S
分子量 334.389
别名 甲基硫酸新斯的明 ;Neostigmine (methyl sulfate);Hodostin;NSC 93753;Neostigmeth;Syntostigmin
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,Store in freezer, under -20°C

溶解方案

DMSO: 105 mg/mL(314.01 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 100 mg/mL(299.05 mM),配合低频超声助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
配制的工作液建议现用现配,短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
动物实验配方
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