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Mometasone furoate
糠酸莫美他松 /Mometasone furoate
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货号：A133834
同义名：
糠酸莫米松
/ Sch32088
Mometasone furoate is a prodrug of mometasone with high affinity for glucocorticoid receptor.
Mometasone furoate 化学结构
Mometasone furoate 3D分子结构
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Mometasone furoate 纯度/质量文件 产品仅供科研
货号：A133834
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Mometasone furoate 质控信息
Mometasone furoate 生物活性
描述
Mometasone furoate is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity. Mometasone furoate acts as a corticosteroid agent and used for topical applications in chronic skin eczema and airway inflammation management of asthma in vivo. Mometasone furoate exhibits high potency with greater anti-inflammatory activity and a longer duration of action than betamethasone. The molecular biotransformation of mometasone furoate in the skin results in a lower affinity with dermal cells than epidermal cells, which contributes to its low atrophogenicity[3] [4]
Mometasone furoate 参考文献
[1] Magari M, Ikeda M, et al. Suppressive effects of mometasone furoate on an antigen-specific IgE antibody response and production of IL-4 in mice. Immunopharmacol Immunotoxicol. 2006;28(3):491-500.
[2] Tsumuro T, Ogawa M, et al. Effects of mometasone furoate on a rat allergic rhinitis model. Eur J Pharmacol. 2005 Nov 7;524(1-3):155-8.
[3] Spada F, Barnes TM, Greive KA. Comparative safety and efficacy of topical mometasone furoate with other topical corticosteroids. Australas J Dermatol. 2018 Aug;59(3):e168-e174
[4] Ho AY, Olm-Shipman M, Zhang Z, Siu CT, Wilgucki M, Phung A, Arnold BB, Porinchak M, Lacouture M, McCormick B, Powell SN, Gelblum DY. A Randomized Trial of Mometasone Furoate 0.1% to Reduce High-Grade Acute Radiation Dermatitis in Breast Cancer Patients Receiving Postmastectomy Radiation. Int J Radiat Oncol Biol Phys. 2018 Jun 1;101(2):325-333
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Mometasone furoate 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
1.92mL
0.38mL
0.19mL
9.59mL
1.92mL
0.96mL
19.18mL
3.84mL
1.92mL
Mometasone furoate 技术信息
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